{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:36:16Z","timestamp":1790422576684,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,3,16]],"date-time":"2007-03-16T00:00:00Z","timestamp":1174003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To clarify the role of macrophage class A scavenger receptors (SR\u2010A, CD204) in oxidative lung injury, we examined lung tissue of SR\u2010A deficient (SR\u2010A<jats:sup>\u2212\/\u2212<\/jats:sup>) and wild\u2010type (SR\u2010A<jats:sup>+\/+<\/jats:sup>) mice in response to hyperoxic treatment. Protein levels of bronchoalveolar lavage fluid (BALF) and pulmonary oedema (wet : dry weight ratios) were higher in SR\u2010A<jats:sup>\u2212\/\u2212<\/jats:sup> mice than those in SR\u2010A<jats:sup>+\/+<\/jats:sup> mice. Cumulative survival was significantly decreased in SR\u2010A<jats:sup>\u2212\/\u2212<\/jats:sup> mice. However, there were no differences in BALF macrophage and neutrophil count between the two groups. Real\u2010time reverse transcriptase\u2010polymerase chain reaction (RT\u2010PCR) revealed that messenger RNA (mRNA) levels of the inducible nitric oxide synthase (iNOS) were increased during hyperoxic injury, and this increase was more prominent in SR\u2010A<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Expression levels of iNOS in alveolar macrophages after hyperoxia <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> were higher in SR\u2010A<jats:sup>\u2212\/\u2212<\/jats:sup> macrophages compared with SR\u2010A<jats:sup>+\/+<\/jats:sup> macrophages. Immunohistochemistry using anti\u2010nitrotyrosine antibodies revealed distinctive oxidative stress in the injured lung in both groups, but it was more remarkable in the SR\u2010A<jats:sup>\u2212\/\u2212<\/jats:sup> mice. After hyperoxic treatment, pulmonary mRNA levels of tumour necrosis factor\u2010\u03b1(TNF\u2010\u03b1) were elevated more rapidly in SR\u2010A<jats:sup>\u2212\/\u2212<\/jats:sup> mice than in SR\u2010A<jats:sup>+\/+<\/jats:sup> mice. Together these results suggest that SR\u2010A expression attenuates hyperoxia\u2010induced lung injury by reducing macrophage activation. Copyright \u00a9 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2150","type":"journal-article","created":{"date-parts":[[2007,3,16]],"date-time":"2007-03-16T15:32:30Z","timestamp":1174059150000},"page":"38-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Class A scavenger receptor (CD204) attenuates hyperoxia\u2010induced lung injury by reducing oxidative stress"],"prefix":"10.1002","volume":"212","author":[{"given":"H","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Sakashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Okuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Terasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tsujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Nomori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kawasuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Takeya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,16]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.1999.00829.x"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.45.5.699"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02715655"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11030745"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-10"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007096931078"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.3109\/01902149509031761"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.6.H2565"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.4.4218"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-5-11"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117607"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/386292a0"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat1994.4.1"},{"key":"e_1_2_7_15_2","first-page":"423","article-title":"Role of macrophage scavenger receptors in diet\u2010induced atherosclerosis in mice","volume":"78","author":"Sakaguchi H","year":"1998","journal-title":"Lab Invest"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)53430-X"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.1995.1038"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(01)12002-4"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2005.12.006"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.186.9.1431"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00474.2004"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2006.00502.x"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1667"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00624-4"},{"key":"e_1_2_7_25_2","first-page":"123","article-title":"Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptative doses of oxygen","volume":"122","author":"Crapo JD","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00008.2003"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117607"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0948fje"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.281.2.L377"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302113280605"},{"key":"e_1_2_7_31_2","first-page":"340","article-title":"Inducible nitric oxide synthase in pulmonary inflammatory processes","volume":"52","author":"Schulz C","year":"1998","journal-title":"Pneumologie"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.12.9337148"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780436"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2005.08.013"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1515\/bchm3.1994.375.2.81"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/34923"},{"key":"e_1_2_7_37_2","first-page":"365","article-title":"Cytokine response during hyperoxia: sequential production of pulmonary tumor necrosis factor and interleukin\u20106 in neonatal rats","volume":"2","author":"Ben\u2010Ari J","year":"2000","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0954-6111(98)90195-0"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199310001-00004"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.70.1.142"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0504270"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200113903"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00279-X"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.5.L905"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.2150","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.2150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T10:33:29Z","timestamp":1761042809000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.2150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,16]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1002\/path.2150"],"URL":"https:\/\/doi.org\/10.1002\/path.2150","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,16]]},"assertion":[{"value":"2006-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-03-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}