{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:10:56Z","timestamp":1761045056737,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T00:00:00Z","timestamp":1182384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pathogenesis of mature T\u2010cell non\u2010Hodgkin lymphomas (T\u2010NHLs) is poorly understood. Analogous to B\u2010cell lymphomas, in which the immunoglobulin (IgH) receptor loci are frequently targeted by chromosomal translocations, the T\u2010cell receptor (TCR) gene loci are affected by translocations in a subset of precursor T\u2010cell malignancies. In a large\u2010scale analysis of 245 paraffin\u2010embedded mature T\u2010NHLs, arranged in a tissue microarray format and using improved FISH assays for the detection of breakpoints in the TCR\u03b1\/\u03b4, TCR\u03b2, and TCR\u03b3 loci, we provide evidence that mature T\u2010NHLs other than T\u2010cell prolymphocytic leukaemia (T\u2010PLL) also occasionally show a chromosomal rearrangement that involves the TCR\u03b1\/\u03b4 locus. In particular, one peripheral T\u2010cell lymphoma (not otherwise specified, NOS) with the morphological variant of Lennert lymphoma displayed a chromosomal translocation t(14;19) involving the TCR\u03b1\/\u03b4 and the <jats:italic>BCL3<\/jats:italic> loci. A second case, an angio\u2010immunoblastic T\u2010cell lymphoma (AILT), carried an inv(14)(q11q32) affecting the TCR\u03b1\/\u03b4 and IgH loci. FISH signal constellations as well as concomitant comparative genomic hybridization (CGH) data were also suggestive of the occurrence of an isochromosome 7, previously described to be pathognomonic for hepatosplenic T\u2010cell lymphomas, in rare cases of enteropathy\u2010type T\u2010cell lymphoma. Copyright \u00a9 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2196","type":"journal-article","created":{"date-parts":[[2007,6,21]],"date-time":"2007-06-21T08:17:18Z","timestamp":1182413838000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Tissue microarray\u2010based screening for chromosomal breakpoints affecting the T\u2010cell receptor gene loci in mature T\u2010cell lymphomas"],"prefix":"10.1002","volume":"213","author":[{"given":"E","family":"Leich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Haralambieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Zettl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Chott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"R\u00fcdiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"H\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u2010K","family":"M\u00fcller\u2010Hermelink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Ott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Rosenwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,9]]},"reference":[{"volume-title":"World Health Organization Classification of Tumors. 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