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In contrast, the neoplastic cells found in lymphocyte predominant Hodgkin's lymphoma (LPHL) (L&amp;H cells) are traditionally thought of as possessing the full repertoire of features associated with germinal centre B cells (eg BCL\u20106 expression, \u2018ongoing\u2019 Ig gene mutation). In the present paper, we report an extensive phenotypic analysis of L&amp;H cells which revealed down\u2010regulation of a number of markers associated with the B\u2010cell lineage (eg CD19, CD37) and with the germinal centre maturation stage (eg PAG, LCK). The promoter methylation status of three of these down\u2010regulated genes (CD10, CD19, and LCK) was further studied in microdissected L&amp;H cells, and this revealed that their promoters were unmethylated. In contrast, these genes showed promoter methylation in cell lines derived from CHL. Further investigation of the mechanisms responsible for the deregulation of these molecules in L&amp;H cells may provide new insights into the genetic abnormalities underlying LPHL. Copyright \u00a9 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2242","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T11:46:19Z","timestamp":1192189579000},"page":"429-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Selective loss of B\u2010cell phenotype in lymphocyte predominant Hodgkin 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