{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:23Z","timestamp":1786978343386,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T00:00:00Z","timestamp":1194480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Palmoplantar pustulosis (PPP) is an autoimmune disease characterized by psoriasis\u2010like erythematous lesions on palms and\/or soles due to an abnormal humoral immune response. Tonsillectomy is effectively employed for the treatment of PPP; however, how tonsils are involved in the aetiology of PPP remains unclear. Here we analysed surgically resected palatine tonsils from 36 cases of PPP as well as usual recurrent tonsillitis (RT) as a control. Histological examination revealed that a unique lesion, with lymphoid follicles surrounded by reticular crypt epithelial cells, was more frequently observed in tonsils of patients with PPP than in those with RT (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001; PPP vs RT). Interestingly, crypt epithelial cells in primary cultures derived from PPP tonsils showed marked production of interleukin\u20106 (IL\u20106). Moreover, these epithelial cells from PPP tonsils expressed p53\u2010related transcription factors in their nuclei that were found to contribute to the up\u2010regulation of\n                    <jats:italic>IL\u20106<\/jats:italic>\n                    gene expression. These findings suggest that, at least in part, the specialized lymphoepithelial symbiosis of PPP tonsils, under the control of p53\u2010related factors, may be relevant to the generation of the impaired micro\u2010environment underlying the aberrant production of autoantibodies. Copyright \u00a9 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.2266","type":"journal-article","created":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T09:47:20Z","timestamp":1194515240000},"page":"75-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Tonsillar crypt epithelium of palmoplantar pustulosis secretes interleukin\u20106 to support B\u2010cell development via p63\/p73 transcription 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