{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:24:53Z","timestamp":1790861093097,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,4,14]],"date-time":"2008-04-14T00:00:00Z","timestamp":1208131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Adult stem cells are thought to be responsible for the high regenerative capacity of the human endometrium, and have been implicated in the pathology of endometriosis and endometrial carcinoma. The RNA\u2010binding protein Musashi\u20101 is associated with maintenance and asymmetric cell division of neural and epithelial progenitor cells. We investigated expression and localization of Musashi\u20101 in endometrial, endometriotic and endometrial carcinoma tissue specimens of 46 patients. qPCR revealed significantly increased\n                    <jats:italic>Musashi\u20101<\/jats:italic>\n                    mRNA expression in the endometrium compared to the myometrium. Musashi\u20101 protein expression presented as nuclear or cytoplasmic immunohistochemical staining of single cells in endometrial glands, and of single cells and cell groups in the endometrial stroma. Immunofluorescence microscopy revealed colocalization of Musashi\u20101 with its molecular target Notch\u20101 and telomerase. In proliferative endometrium, the proportion of Musashi\u20101\u2010positive cells in the basalis layer was significantly increased 1.5\u2010fold in the stroma, and three\u2010fold in endometrial glands compared to the functionalis. The number of Musashi\u20101 expressing cell groups was significantly increased (four\u2010fold) in proliferative compared to secretory endometrium. Musashi\u20101 expressing stromal cell and cell group numbers were significantly increased (five\u2010fold) in both endometriotic and endometrial carcinoma tissue compared to secretory endometrium. A weak to moderate, diffuse cytoplasmic glandular staining was observed in 50% of the endometriosis cases and in 75% of the endometrioid carcinomas compared to complete absence in normal endometrial samples. Our results emphasize the role of Musashi\u20101\u2010expressing endometrial progenitor cells in proliferating endometrium, endometriosis and endometrioid uterine carcinoma, and support the concept of a stem cell origin of endometriosis and endometrial carcinoma. Copyright \u00a9 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.2364","type":"journal-article","created":{"date-parts":[[2008,4,14]],"date-time":"2008-04-14T08:19:11Z","timestamp":1208161151000},"page":"317-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":171,"title":["Increased expression of the adult stem cell marker Musashi\u20101 in endometriosis and endometrial 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