{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:01:19Z","timestamp":1791273679899,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,7,14]],"date-time":"2008-07-14T00:00:00Z","timestamp":1215993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The molecular feature of Burkitt lymphoma (BL) is the translocation that places c\u2010Myc under the control of immunoglobulin gene regulatory elements. However, there is accumulating evidence that some cases may lack an identifiable <jats:italic>MYC<\/jats:italic> translocation. In addition, during the EUROFISH project, aiming at the standardization of FISH procedures in lymphoma diagnosis, we found that five cases out of 35 classic endemic BLs were negative for <jats:italic>MYC<\/jats:italic> translocations by using a split\u2010signal as well as a dual\u2010fusion probe. Here we investigated the expression pattern of miRNAs predicted to target c\u2010Myc, in BL cases, to clarify whether alternative pathogenetic mechanisms may be responsible for lymphomagenesis in cases lacking the <jats:italic>MYC<\/jats:italic> translocation. miRNAs are a class of small RNAs that are able to regulate gene expression at the post\u2010transcriptional level. Several studies have reported their involvement in cancer and their association with fragile sites in the genome. They have also been shown to control cell growth, differentiation, and apoptosis, suggesting that these molecules could act as tumour suppressors or oncogenes. Our results demonstrated a modulation of specific miRNAs. In particular, down\u2010regulation of hsa\u2010let\u20107c was observed in BL cases, compared to normal controls. More interestingly, hsa\u2010mir\u201034b was found to be down\u2010regulated only in BL cases that were negative for <jats:italic>MYC<\/jats:italic> translocation, suggesting that this event might be responsible for c\u2010Myc deregulation in such cases. This hypothesis was further confirmed by our <jats:italic>in vitro<\/jats:italic> experiments, which demonstrated that increasing doses of synthetic hsa\u2010mir\u201034b were able to modulate c\u2010Myc expression. These results indicate for the first time that hsa\u2010mir\u201034b may influence c\u2010Myc expression in Burkitt lymphoma as the more common aberrant control exercised by the immunoglobulin enhancer locus. Copyright \u00a9 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2410","type":"journal-article","created":{"date-parts":[[2008,7,14]],"date-time":"2008-07-14T10:26:29Z","timestamp":1216031189000},"page":"440-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":168,"title":["<i>MYC<\/i> translocation\u2010negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation"],"prefix":"10.1002","volume":"216","author":[{"given":"E","family":"Leucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Cocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Onnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"De 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