{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:07:28Z","timestamp":1791119248667,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,7,29]],"date-time":"2008-07-29T00:00:00Z","timestamp":1217289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Infection of \u03b3\u03b4T cell\u2010deficient (TcR\u03b4<jats:sup>\u2212\/\u2212<\/jats:sup>) mice with the intracellular bacterium <jats:italic>Listeria monocytogenes<\/jats:italic> (<jats:italic>Lm<\/jats:italic>) results in an exacerbated inflammatory response characterized by the accumulation of activated macrophages and necrotic liver lesions. Here we investigated whether changes in chemokine production by <jats:italic>Lm<\/jats:italic>\u2010elicited macrophages contribute to this abnormal inflammatory response. In response to <jats:italic>Lm<\/jats:italic> infection, activated macrophages accumulate in the primary sites of infection in TcR\u03b4<jats:sup>\u2212\/\u2212<\/jats:sup> mice and express high amounts of mRNA encoding the chemokines CCL3 (MIP\u20101\u03b1), CCL4 (MIP\u20101\u03b2), CXCL2 (MIP\u20102) and CXCL10 (IP\u201010). In the infected tissues of TcR\u03b4<jats:sup>\u2212\/\u2212<\/jats:sup> the number of chemokine\u2010synthesizing macrophages was higher than in wild\u2010type (WT) mice, with the amount of MIP\u20101\u03b1 and MIP\u20101\u03b2 secreted by individual macrophages in the spleen of TcR\u03b4<jats:sup>\u2212\/\u2212<\/jats:sup> mice also being significantly higher than in WT mice. By contrast, protease activity and NO production in individual splenic macrophages of <jats:italic>Lm<\/jats:italic>\u2010infected TcR\u03b4<jats:sup>\u2212\/\u2212<\/jats:sup> and WT mice were comparable. Pathogen\u2010elicited macrophages in TcR\u03b4<jats:sup>\u2212\/\u2212<\/jats:sup> mice also expressed high levels of the CCL3 and CCL4 receptor, CCR5. In macrophage\u2010\u03b3\u03b4T cell co\u2010cultures, chemokine\u2010producing macrophages were killed by cytotoxic V\u03b31<jats:sup>+<\/jats:sup> T cells in a Fas\u2013FasL\u2010dependent manner consistent with the high levels of chemokine\u2010producing macrophages seen in infected TcR\u03b4<jats:sup>\u2212\/\u2212<\/jats:sup> mice being due to the absence of V\u03b31<jats:sup>+<\/jats:sup> T cells. Together these findings highlight the importance of \u03b3\u03b4T cells in regulating macrophage anti\u2010microbial responses. Copyright \u00a9 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2412","type":"journal-article","created":{"date-parts":[[2008,7,29]],"date-time":"2008-07-29T09:14:16Z","timestamp":1217322856000},"page":"262-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["\u03b3\u03b4T cell\u2010mediated regulation of chemokine producing macrophages during <i>Listeria monocytogenes<\/i> infection\u2010induced 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