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We compared the genetic profiles of 33 ocular adnexal and 25 pulmonary MALT lymphomas by 1 Mb array\u2013comparative genomic hybridization (CGH) and revealed recurrent 6q23 losses and 6p21.2\u20136p22.1 gains exclusive to ocular cases. High\u2010resolution chromosome 6 tile\u2010path array\u2013CGH identified NF\u2010\u03baB inhibitor <jats:italic>A20<\/jats:italic> as the target of 6q23.3 deletion and <jats:italic>TNFA\/B\/C<\/jats:italic> locus as a putative target of 6p21.2\u201322.1 gain. Interphase fluorescence <jats:italic>in situ<\/jats:italic> hybridization showed that <jats:italic>A20<\/jats:italic> deletion occurred in MALT lymphoma of the ocular adnexa (8\/42 = 19%), salivary gland (2\/24 = 8%), thyroid (1\/9 = 11%) and liver (1\/2), but not in the lung (26), stomach (45) and skin (13). Homozygous deletion was observed in three cases. <jats:italic>A20<\/jats:italic> deletion and <jats:italic>TNFA\/B\/C<\/jats:italic> gain were significantly associated (<jats:italic>p<\/jats:italic> &lt; 0.001) and exclusively found in cases without characteristic translocation. In ocular cases, <jats:italic>A20<\/jats:italic> deletion was associated with concurrent involvement of different adnexal tissues or extraocular sites at diagnosis (<jats:italic>p<\/jats:italic> = 0.007), a higher proportion of relapse (67% versus 37%) and a shorter relapse\u2010free survival (<jats:italic>p<\/jats:italic> = 0.033). <jats:italic>A20<\/jats:italic> deletion and gain at <jats:italic>TNFA\/B\/C<\/jats:italic> locus may thus play an important role in the development of translocation\u2010negative MALT lymphoma. Copyright \u00a9 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2466","type":"journal-article","created":{"date-parts":[[2008,10,9]],"date-time":"2008-10-09T08:39:13Z","timestamp":1223541553000},"page":"420-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["<i>A20<\/i> deletion is associated with copy number gain at the <i>TNFA\/B\/C<\/i> locus and occurs preferentially in translocation\u2010negative MALT lymphoma of the ocular adnexa and salivary 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