{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:49:07Z","timestamp":1769550547169,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,11,4]],"date-time":"2008-11-04T00:00:00Z","timestamp":1225756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dupuytren's disease (DD) is a fibromatosis characterized by non\u2010malignant transformation of palmar fascia leading to permanent contraction of one or more fingers. Despite the extensive knowledge of its clinical pathogenesis, the aetiology of this disease remains obscure. In the present paper, we report for the first time on the proteomic profiling of diseased versus unaffected patient\u2010matched palmar fasciae tissues from DD patients using two\u2010dimensional gel electrophoresis coupled with mass spectrometry analysis. The herein identified proteins were then used to create the protein\u2013protein interaction network (interactome). Such an integrated approach revealed the involvement of several different molecular processes related to DD progression, including extra\u2010 and intra\u2010cellular signalling, oxidative stress, cytoskeletal changes, and alterations in cellular metabolism. In particular, autocrine regulation through ERBB\u20102 and IGF\u20101R receptors and the Akt signalling pathway have emerged as novel components of pro\u2010survival signalling in Dupuytren's fibroblasts and thus might provide a basis for a new therapeutic strategy in Dupuytren's disease. Copyright \u00a9 2008 Pathological Society of Great Britain and Ireland. 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