{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:07:51Z","timestamp":1791241671009,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T00:00:00Z","timestamp":1253836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In their paper in this issue of the Journal, Xian <jats:italic>et al<\/jats:italic> have analysed in detail the Fallopian tubes from two patients with Li\u2013Fraumeni syndrome (germline <jats:italic>TP53<\/jats:italic> mutation) in order to investigate further the possible role of p53 signatures in the development of high\u2010grade pelvic serous carcinoma. They find an increased frequency of p53 signatures, with associated evidence of DNA damage and loss of heterozygosity at the wild\u2010type <jats:italic>TP53<\/jats:italic> allele, but postulate, as Li\u2013Fraumeni syndrome is not associated with an increased risk of pelvic serous carcinoma, that these events are not sufficient for the development of carcinoma. Rather, they put forward a model postulating that further events, particularly loss of BRCA1\/2 function, are required for lesion progression. This paper exemplifies how the hypothesis\u2010driven study of a rare syndrome can be highly effective at answering specific questions about disease processes. It is of note that recent evidence from the same group provides convincing evidence that the distal Fallopian tube may, in fact, be the commonest site of origin for high\u2010grade pelvic serous carcinomas, most of which may originate at this site rather than from the ovary. In addition to its biological significance, this, if proven, has clear clinical implications. Copyright \u00a9 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2630","type":"journal-article","created":{"date-parts":[[2009,9,25]],"date-time":"2009-09-25T14:23:33Z","timestamp":1253888613000},"page":"5-6","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The emerging role of the distal Fallopian tube and p53 in pelvic serous carcinogenesis"],"prefix":"10.1002","volume":"220","author":[{"given":"C Simon","family":"Herrington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W Glenn","family":"McCluggage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,30]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000130446.84670.93"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63708-X"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e3181b4fffa"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1563"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb01528.x"},{"key":"e_1_2_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000201826.46978.e5"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213335.40358.47"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2091"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.01.012"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b013e31814b191f"},{"key":"e_1_2_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02938.x"},{"key":"e_1_2_2_13_2","article-title":"The Li Fraumeni syndrome (LFS): a model for the initiation of p53 signatures in the distal Fallopian tube","author":"Xian W","year":"2009","journal-title":"J Pathol"},{"key":"e_1_2_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2552"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.197"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181868904"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.2630","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.2630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.2630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:56:19Z","timestamp":1761047779000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.2630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,30]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1002\/path.2630"],"URL":"https:\/\/doi.org\/10.1002\/path.2630","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,30]]},"assertion":[{"value":"2009-09-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-10-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}