{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:46:48Z","timestamp":1792450008890,"version":"4.5.0"},"reference-count":150,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T00:00:00Z","timestamp":1263859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypoxia\u2010inducible factor (HIF) plays an important role in renal tumourigenesis. In the majority of clear cell RCC (ccRCC), the most frequent and highly vascularized RCC subtype, HIF is constitutively activated by inactivation of the von Hippel\u2013Lindau gene. Of the HIF subunits, HIF\u20102\u03b1 appears to be more oncogenic than HIF\u20101\u03b1, in that HIF\u20102\u03b1 activates pro\u2010tumourigenic target genes. In addition, recent studies indicate that HIF\u20101\u03b1, more than HIF\u20102\u03b1, can undergo proteasomal degradation in VHL \u2212 \/\u2212 RCC cells. A more detailed understanding of the molecular basis of hypoxia and angiogenesis in renal carcinogenesis has set the stage for the development of targeted therapies, inhibiting multiple HIF\u2010related pathways, such as the phosphatidylinositol 3\u2010kinase\u2013AKT\u2013mTOR, RAS\/RAF\/MAP, and VEGF signalling routes. However, despite the positive results of these targeting agents in progression\u2010free survival, clinical resistance remains an issue. Recent pre\u2010clinical studies have suggested new targeting approaches such as inhibition of HIF\u2010driven key metabolic enzymes and have introduced new HIF targeting agents, such as histone deacetylase inhibitors, with successful anti\u2010neoplastic effects. In this review, we discuss existing and novel findings about RCC carcinogenesis, with subsequent clinical implications. Copyright \u00a9 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2689","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T06:43:04Z","timestamp":1263883384000},"page":"125-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":270,"title":["VHL and HIF signalling in renal cell carcinogenesis"],"prefix":"10.1002","volume":"221","author":[{"given":"Marcella M","family":"Baldewijns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris JH","family":"van Vlodrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia MMB","family":"Soetekouw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"van Engeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan P","family":"de Bru\u00efne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,5,4]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1364"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1187"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.15.1.551"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.9.2984-2992.2002"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.17.11205"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059796"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704988200"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg392"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02041-07"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/35017054"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-4564"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01514-06"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-579X(02)00103-7"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2397"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1716"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.01.001"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.9.8303"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1865"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3074"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00071-5"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.06.017"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng849"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.11.022"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/381054"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.03.015"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.12.010"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio0308-152"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810067106"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1870"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0597-68"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.10.016"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1081\/CNV-200027144"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880275"},{"key":"e_1_2_9_35_2","first-page":"5173","article-title":"Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin","volume":"63","author":"El\u2010Hashemite N","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_9_36_2","first-page":"2675","article-title":"Up\u2010regulation of hypoxia\u2010inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc\u20102 tumor suppressor gene","volume":"63","author":"Liu MY","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00187-9"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.08.008"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(05)80048-6"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/20459"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0000083"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.13.5675-5686.2005"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700704200"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601300"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204733200"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.6.2019-2028.2006"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.04.009"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.08.026"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e06-05-0419"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603675"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.02.006"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.07.006"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2008.10.016"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.02.002"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.012"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-007-9088-8"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200300464"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500811"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh104"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-040031"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.5.759"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00610.x"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.009894"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-669"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)99049-6"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.07.121"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00278-0"},{"key":"e_1_2_9_68_2","first-page":"4233","article-title":"Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis","volume":"54","author":"Takahashi A","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603796"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200302047"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.054"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.64"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1520"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507443102"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210186"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1840"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-062398"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.3892\/ijo_00000318"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.07.020"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2007.01.019"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.061"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.1.3668"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08-06-0566"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00892-06"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2670"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3719"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006020181"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200605092"},{"key":"e_1_2_9_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb899"},{"key":"e_1_2_9_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.08.050"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1579"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00232-06"},{"key":"e_1_2_9_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1912"},{"key":"e_1_2_9_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80096-9"},{"key":"e_1_2_9_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210709"},{"key":"e_1_2_9_96_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.7.2519-2530.2006"},{"key":"e_1_2_9_97_2","first-page":"2929","article-title":"Role of the von Hippel\u2013Lindau tumor suppressor gene in the formation of beta1\u2010integrin fibrillar adhesions","volume":"62","author":"Esteban\u2010Barragan MA","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.04.006"},{"key":"e_1_2_9_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.09.010"},{"key":"e_1_2_9_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.35"},{"key":"e_1_2_9_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10152"},{"key":"e_1_2_9_102_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208912"},{"key":"e_1_2_9_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210474"},{"key":"e_1_2_9_104_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01231-07"},{"key":"e_1_2_9_105_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.9.5902"},{"key":"e_1_2_9_106_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606850103"},{"key":"e_1_2_9_107_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-1-107"},{"key":"e_1_2_9_108_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065044"},{"key":"e_1_2_9_109_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060655"},{"key":"e_1_2_9_110_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2530"},{"key":"e_1_2_9_111_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.1293"},{"key":"e_1_2_9_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2009.09.002"},{"key":"e_1_2_9_113_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta14020"},{"key":"e_1_2_9_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61904-7"},{"key":"e_1_2_9_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605167"},{"key":"e_1_2_9_116_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2231"},{"key":"e_1_2_9_117_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3341"},{"key":"e_1_2_9_118_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0311171"},{"key":"e_1_2_9_119_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066838"},{"key":"e_1_2_9_120_2","doi-asserted-by":"publisher","DOI":"10.3816\/CGC.2007.n.020"},{"key":"e_1_2_9_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61039-9"},{"key":"e_1_2_9_122_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24229"},{"key":"e_1_2_9_123_2","doi-asserted-by":"publisher","DOI":"10.3747\/co.v16i0.407"},{"key":"e_1_2_9_124_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24409"},{"key":"e_1_2_9_125_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-009-9177-0"},{"key":"e_1_2_9_126_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22677"},{"key":"e_1_2_9_127_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0706596"},{"key":"e_1_2_9_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.01.021"},{"key":"e_1_2_9_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.01.027"},{"key":"e_1_2_9_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.02.007"},{"key":"e_1_2_9_131_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0310"},{"key":"e_1_2_9_132_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.5154"},{"key":"e_1_2_9_133_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141478"},{"key":"e_1_2_9_134_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0617"},{"key":"e_1_2_9_135_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2346"},{"key":"e_1_2_9_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2006.04.023"},{"key":"e_1_2_9_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.09.002"},{"key":"e_1_2_9_138_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00603.x"},{"key":"e_1_2_9_139_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00436.x"},{"key":"e_1_2_9_140_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08759.x"},{"key":"e_1_2_9_141_2","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.7.10.6584"},{"key":"e_1_2_9_142_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200111000-00010"},{"key":"e_1_2_9_143_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.8.2873-2884.2005"},{"key":"e_1_2_9_144_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1918"},{"key":"e_1_2_9_145_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C800170200"},{"key":"e_1_2_9_146_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2925"},{"key":"e_1_2_9_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.05.008"},{"key":"e_1_2_9_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2008.09.024"},{"key":"e_1_2_9_149_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2779"},{"key":"e_1_2_9_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.020"},{"key":"e_1_2_9_151_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104819"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.2689","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.2689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:56:52Z","timestamp":1761058612000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.2689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,4]]},"references-count":150,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/path.2689"],"URL":"https:\/\/doi.org\/10.1002\/path.2689","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,4]]},"assertion":[{"value":"2009-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}