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The histopathological and molecular genetic characterization of anaplastic plasmacytoma (APCT) in strain NSF.V<jats:sup>+<\/jats:sup> mice provides an example to achieve this goal for a specific lymphoma subtype. Firstly, it demonstrates that, like plasma\u2010cell neoplasms in humans, those in mice occur as distinct subtypes. Secondly, it shows that mouse APCT exhibits striking parallels to possible human tumour counterparts for which good mouse models of <jats:italic>de novo<\/jats:italic> tumour development are sorely needed: IgM<jats:sup>+<\/jats:sup> multiple myeloma and Waldenstr\u00f6m's macroglobulinaemia. Thirdly, it strongly suggests that insertional somatic mutagenesis, by either a murine leukaemia virus or an oncogenic transposon, would be an effective experimental approach to accelerating malignant transformation of mature B cells and plasma cells in mice and, thereby, tagging and uncovering cancer driver genes that may be of great relevance for the tumour initiation and progression in lymphoma. Copyright \u00a9 2010 Pathological Society of Great Britain and Ireland. 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