{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:35:40Z","timestamp":1790937340439,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T00:00:00Z","timestamp":1274400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NCI","award":["1R21CA124688-01A1"],"award-info":[{"award-number":["1R21CA124688-01A1"]}]},{"name":"Columbia Hospital for Women Research Foundation"},{"name":"Francis Ward Paine"},{"name":"TSA Pemberton Funds"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The \u2018p53 signature\u2019 is a benign secretory cell outgrowth in the distal Fallopian tube that shares properties with ovarian serous cancer\u2014including p53 mutations\u2014and is a putative serous cancer precursor. We expanded the precursor definition to all secretory cell outgrowths (SCOUTs) of 30 or more cells and scored normal (N) and altered (A) expression of both <jats:italic>p53<\/jats:italic> and <jats:italic>PAX2<\/jats:italic>, a gene down\u2010regulated in ovarian and endometrial cancer. SCOUTs were identified by BCL2\/p73 staining in tubes from women with serous carcinoma, inherited mutations in <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> and controls. SCOUTs were prevalent in <jats:italic>both<\/jats:italic> proximal and distal tube and significantly associated with serous carcinoma versus the others (<jats:italic>p<\/jats:italic> &lt; 0.001); 89% were PAX2 (A) and 26% were PAX2 (A)\/p53 (A) (p53 signatures). PAX2 (A)\/p53 (N) SCOUTs were free of p53 mutations; however, 12 of 13 p53 signatures were PAX2 (A). A tubal carcinoma and contiguous SCOUT were p53 (A)\/PAX2 (A) and shared the same <jats:italic>p53<\/jats:italic> mutation. SCOUTs are discretely localized alterations commonly containing altered expression of multiple genes within histologically benign tubal epithelium. Geographic distribution in the tube varies by genotype and immunophenotype, from regionally unrestricted (PAX2) to greater likelihood specific area (fimbria) of shared prevalence (PAX2 and p53). This study reveals, for the first time, an entity (SCOUT) that is associated with serous cancer, expands the topography of altered PAX2 expression in the female genital tract mucosa and highlights another potential pathway disturbance involved in early serous carcinogenesis in the Fallopian tube. Copyright \u00a9 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2739","type":"journal-article","created":{"date-parts":[[2010,5,25]],"date-time":"2010-05-25T05:49:21Z","timestamp":1274766561000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Secretory cell outgrowth, PAX2 and serous carcinogenesis in the Fallopian tube"],"prefix":"10.1002","volume":"222","author":[{"given":"Eleanor 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