{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:57:45Z","timestamp":1780333065328,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T00:00:00Z","timestamp":1275955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The integrin \u03b1v\u03b26 is expressed only on epithelia and then usually only during processes of tissue remodelling including cancer, where its high expression correlates with reduced survival. Thus, \u03b1v\u03b26 represents an important target for imaging and therapy of cancer and new molecular\u2010specific targeting agents are required. We have developed A20FMDV2, a peptide derived from the VP1 coat protein of foot\u2010and\u2010mouth\u2010disease virus that binds specifically and stably to \u03b1v\u03b26. Using a newly generated pair of isogenic human cell lines that differ only in \u03b1v\u03b26 expression, it was shown, using biodistribution and SPECT imaging, that indium\u2010111\u2010labelled A20FMDV2 locates specifically to \u03b1v\u03b26\u2010expressing tissues <jats:italic>in vivo<\/jats:italic>, achieving at least seven\u2010times higher retention in \u03b1v\u03b26\u2010positive than in \u03b1v\u03b26\u2010negative tumours. In further studies with MCF10.DCIS.COM and MCF10A.CA1a breast carcinoma cell lines, which express \u03b1v\u03b26 endogenously, the radiopeptide achieved similar levels of tumour retention and permitted excellent discriminatory imaging of tumours. Thus, A20FMDV2 can be used for molecular\u2010specific targeting of \u03b1v\u03b26 for imaging <jats:italic>in vivo<\/jats:italic> the often more aggressive, \u03b1v\u03b26\u2010positive cancers. In the future, A20FMDV2 could serve also to deliver therapy to these same cancers. Copyright \u00a9 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.2745","type":"journal-article","created":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T08:04:23Z","timestamp":1275984263000},"page":"52-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["High\u2010resolution <i>in vivo<\/i> imaging of breast cancer by targeting the pro\u2010invasive integrin \u03b1v\u03b26"],"prefix":"10.1002","volume":"222","author":[{"given":"Antonio","family":"Saha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ellison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth 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