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Deregulated Notch signalling has been implicated in many diseases, but the clearest example of a pathogenic role is found in T\u2010cell lymphoblastic leukaemia\/lymphoma (T\u2010LL), in which the majority of human and murine tumours have acquired mutations that lead to aberrant increases in Notch1 signalling. Remarkably, it appears that the selective pressure for Notch mutations is virtually unique among cancers to T\u2010LL, presumably reflecting a special context\u2010dependent role for Notch in normal T\u2010cell progenitors. Nevertheless, there are some recent reports suggesting that Notch signalling has subtle, yet important roles in other forms of haematological malignancy as well. Here, we review the role of Notch signalling in various blood cancers, focusing on T\u2010LL with an eye towards targeted therapeutics. Copyright \u00a9 2010 Pathological Society of Great Britain and Ireland. 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