{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:31:39Z","timestamp":1792715499430,"version":"4.5.0"},"reference-count":140,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,11,21]],"date-time":"2011-11-21T00:00:00Z","timestamp":1321833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary cilia are microtubule\u2010based sensory organelles that coordinate signalling pathways in cell\u2010cycle control, migration, differentiation and other cellular processes critical during development and for tissue homeostasis. Accordingly, defects in assembly or function of primary cilia lead to a plethora of developmental disorders and pathological conditions now known as ciliopathies. In this review, we summarize the current status of the role of primary cilia in coordinating receptor tyrosine kinase (RTK) signalling pathways. Further, we present potential mechanisms of signalling crosstalk and networking in the primary cilium and discuss how defects in ciliary RTK signalling are linked to human diseases and disorders. Copyright \u00a9 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.3004","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T08:16:36Z","timestamp":1317197796000},"page":"172-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":175,"title":["Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling"],"prefix":"10.1002","volume":"226","author":[{"given":"S\u00f8ren T","family":"Christensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A","family":"Clement","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Satir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte B","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.050377"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.7.080505.115610"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2278"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1010172"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2006.00516.x"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2010.03.010"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.042308.113337"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.05.030"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.040705.141236"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm952"},{"key":"e_1_2_11_12_2","article-title":"The ciliary cytoskeleton","author":"Pedersen LB","year":"2011","journal-title":"Comprehens Physiol"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200503053"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.15.2.363"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21521"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(08)00802-8"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.059519"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1042\/BC20100128"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.53.2.494"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201006105"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201012116"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191054"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2073"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(08)00805-3"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21753"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e07-09-0942"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405496101"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp031"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1194004"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.053"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200909183"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000208212"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2774"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1731-7"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21554"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)62706-0"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-09-0792"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4020-5943-8_10"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2010.535889"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1042\/BC20110034"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1146180"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02061"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2008011"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90509.2008"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0425-4"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283444d05"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.08.034"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/35077225"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.09.012"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1159\/000276562"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.18.8285-8298.2005"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20741"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1549"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.046276"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2005.03.006"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07753"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812880106"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00180.2002"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0413OC"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1653708"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.4617"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.427"},{"key":"e_1_2_11_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.07.034"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-369-5_11"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(79)90261-7"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm759"},{"key":"e_1_2_11_67_2","first-page":"1321","article-title":"p57: A multifunctional protein in cancer (review)","volume":"36","author":"Guo H","year":"2010","journal-title":"Int J Oncol"},{"key":"e_1_2_11_68_2","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.561318"},{"key":"e_1_2_11_69_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-09-0317"},{"key":"e_1_2_11_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.26"},{"key":"e_1_2_11_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.423"},{"key":"e_1_2_11_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.06.005"},{"key":"e_1_2_11_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2183"},{"key":"e_1_2_11_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.035"},{"key":"e_1_2_11_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2218"},{"key":"e_1_2_11_76_2","first-page":"279","article-title":"The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair","volume":"85","author":"Christensen ST","year":"2008","journal-title":"Curr Top Dev Biol"},{"key":"e_1_2_11_77_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.10.16.17009"},{"key":"e_1_2_11_78_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5838"},{"key":"e_1_2_11_79_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.20125"},{"key":"e_1_2_11_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(77)90109-X"},{"key":"e_1_2_11_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/0248-4900(94)90050-7"},{"key":"e_1_2_11_82_2","doi-asserted-by":"publisher","DOI":"10.1159\/000132462"},{"key":"e_1_2_11_83_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000222690.53970.ca"},{"key":"e_1_2_11_84_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.38.020187.000443"},{"key":"e_1_2_11_85_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.21.9789"},{"key":"e_1_2_11_86_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1185504"},{"key":"e_1_2_11_87_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200806019"},{"key":"e_1_2_11_88_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.029900"},{"key":"e_1_2_11_89_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702373200"},{"key":"e_1_2_11_90_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/148.2.703"},{"key":"e_1_2_11_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00068-9"},{"key":"e_1_2_11_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/414799a"},{"key":"e_1_2_11_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02059"},{"key":"e_1_2_11_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msn036"},{"key":"e_1_2_11_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)51620-3"},{"key":"e_1_2_11_96_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-80481-6_8"},{"key":"e_1_2_11_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07450.x"},{"key":"e_1_2_11_98_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7618084"},{"key":"e_1_2_11_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.03.023"},{"key":"e_1_2_11_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2003.11.007"},{"key":"e_1_2_11_101_2","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.5A6866.2006"},{"key":"e_1_2_11_102_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-001-0075-4"},{"key":"e_1_2_11_103_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.037689"},{"key":"e_1_2_11_104_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvq121"},{"key":"e_1_2_11_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/418037a"},{"key":"e_1_2_11_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81705-5"},{"key":"e_1_2_11_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.03.002"},{"key":"e_1_2_11_108_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021793"},{"key":"e_1_2_11_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.05.568"},{"key":"e_1_2_11_110_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0914396107"},{"key":"e_1_2_11_111_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1017248108"},{"key":"e_1_2_11_112_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3146re9"},{"key":"e_1_2_11_113_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8081-0"},{"key":"e_1_2_11_114_2","first-page":"973","article-title":"Focal adhesion kinase as potential target for cancer therapy (review)","volume":"22","author":"Hao H","year":"2009","journal-title":"Oncol Rep"},{"key":"e_1_2_11_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2010.04.008"},{"key":"e_1_2_11_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.04.002"},{"key":"e_1_2_11_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.12.001"},{"key":"e_1_2_11_118_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2008.01021.x"},{"key":"e_1_2_11_119_2","doi-asserted-by":"publisher","DOI":"10.1042\/CBI20090094"},{"key":"e_1_2_11_120_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21330"},{"key":"e_1_2_11_121_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21501"},{"key":"e_1_2_11_122_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.81"},{"key":"e_1_2_11_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.03.003"},{"key":"e_1_2_11_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2117"},{"key":"e_1_2_11_125_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010050526"},{"key":"e_1_2_11_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2010.108"},{"key":"e_1_2_11_127_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201102090"},{"key":"e_1_2_11_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.06.022"},{"key":"e_1_2_11_129_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.352"},{"key":"e_1_2_11_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700207"},{"key":"e_1_2_11_131_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.630"},{"key":"e_1_2_11_132_2","first-page":"476","article-title":"Mammalian target of rapamycin: a central node of complex signaling cascades","volume":"4","author":"Dobashi Y","year":"2011","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_11_133_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089160409000102"},{"key":"e_1_2_11_134_2","doi-asserted-by":"publisher","DOI":"10.1097\/PDM.0b013e3181eb931b"},{"key":"e_1_2_11_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.02.004"},{"key":"e_1_2_11_136_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000998"},{"key":"e_1_2_11_137_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28984"},{"key":"e_1_2_11_138_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2011.088864"},{"key":"e_1_2_11_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.04.012"},{"key":"e_1_2_11_140_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200706028"},{"key":"e_1_2_11_141_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.085852"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.3004","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.3004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:22:26Z","timestamp":1761049346000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.3004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,21]]},"references-count":140,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1002\/path.3004"],"URL":"https:\/\/doi.org\/10.1002\/path.3004","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,21]]},"assertion":[{"value":"2011-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}