{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:40:29Z","timestamp":1791330029000,"version":"4.3.1"},"reference-count":180,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bile is a complex mixture that includes bile salts, the membrane phospholipid phosphatidylcholine (PC), cholesterol and various endobiotic and xenobiotic toxins, each of which is secreted across the canalicular membrane of the hepatocyte by different ATP\u2010binding cassette (ABC) transporters. The bile salts are essential for the emulsification of dietary fat and lipophilic vitamins. They are synthesized from cholesterol in the hepatocyte and their secretion by the bile salt export pump (BSEP or ABCB11) drives bile flow and is the starting point for the enterohepatic cycle. The detergent nature of bile salts that is key to their physiological role also means that they are inherently cytotoxic, and failure to secrete bile (intraheptic cholestasis) can precipitate severe liver disease and mortality. Such progressive familial intrahepatic cholestasis (PFIC) comes in three types of autosomal recessive disease. PFIC2 is caused by mutation to ABCB11. PFIC3 is caused by mutation of a closely related ABC transporter, ABCB4, which flops PC into the outerleaflet of the canalicular membrane. The flopped PC is extracted by the bile salts in the canaliculus to form a mixed micelle that reduces bile salt detergent activity. The third protein that is essential for bile flow from the hepatocyte is a member of a different class of transporter protein, a P\u2010type ATPase, ATP8B1. Mutation of ATP8B1 causes PFIC1, but ATP8B1 does not transport a component of bile into the canaliculus. Data from different laboratories, published this year, suggests two different roles for ATP8B1 in the hepatocyte: a lipid flippase, that counterbalances the deleterious effects of ABCB4 on barrier function of the canalicular membrane; and an anchor of the actin cytoskeleton necessary to form the microvilli of the brush border. These latest discoveries are described, along with a spectrum of cholestatic disorders whose aetiologies lie in these and other transporters of the canalicular membrane. Copyright \u00a9 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.3019","type":"journal-article","created":{"date-parts":[[2011,10,7]],"date-time":"2011-10-07T17:08:13Z","timestamp":1318007293000},"page":"300-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Canalicular ABC transporters and liver disease"],"prefix":"10.1002","volume":"226","author":[{"given":"Michael","family":"Nicolaou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J","family":"Andress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K","family":"Zolnerciks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J","family":"Linton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1142\/7371"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-7568-6"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161712"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36591"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00135a001"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.2741\/3399"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.06.005"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.64.082201.100300"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2002"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1130-z"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70088-5"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004240000281"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3060241"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.11.4741"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412752200"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301106200"},{"key":"e_1_2_13_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1253226"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R900012-JLR200"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9426"},{"key":"e_1_2_13_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1994.266.3.G382"},{"key":"e_1_2_13_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117091"},{"key":"e_1_2_13_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00352.2002"},{"key":"e_1_2_13_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)33406-4"},{"key":"e_1_2_13_25_2","first-page":"54","article-title":"Functional characterization of the hepatic sodium\u2010dependent taurocholate transporter stably transfected into an immortalized liver\u2010derived cell line and V79 fibroblasts","volume":"70","author":"Platte HD","year":"1996","journal-title":"Eur J Cell Biol"},{"key":"e_1_2_13_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.274.2.G370"},{"key":"e_1_2_13_27_2","first-page":"G801","article-title":"Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile","volume":"269","author":"Meier PJ","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_13_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-003-1168-y"},{"key":"e_1_2_13_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9289-1"},{"key":"e_1_2_13_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(02)00633-8"},{"key":"e_1_2_13_31_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21176"},{"key":"e_1_2_13_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.26.16184"},{"key":"e_1_2_13_33_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26340"},{"key":"e_1_2_13_34_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.069971"},{"key":"e_1_2_13_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00057-3"},{"key":"e_1_2_13_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1969.02100030114014"},{"key":"e_1_2_13_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2010.08.001"},{"key":"e_1_2_13_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.15.6590"},{"key":"e_1_2_13_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840140413"},{"key":"e_1_2_13_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)55151-6"},{"key":"e_1_2_13_41_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2840067"},{"key":"e_1_2_13_42_2","first-page":"2029","article-title":"Identification of a sister gene to P\u2010glycoprotein","volume":"55","author":"Childs S","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_13_43_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.16.10046"},{"key":"e_1_2_13_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/3034"},{"key":"e_1_2_13_45_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36587"},{"key":"e_1_2_13_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.2011"},{"key":"e_1_2_13_47_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi050943e"},{"key":"e_1_2_13_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20682"},{"key":"e_1_2_13_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2003.tb08089.x"},{"key":"e_1_2_13_50_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.119993"},{"key":"e_1_2_13_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70287-8"},{"key":"e_1_2_13_52_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.065"},{"key":"e_1_2_13_53_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22683"},{"key":"e_1_2_13_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-1"},{"key":"e_1_2_13_55_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1272831"},{"key":"e_1_2_13_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.09.013"},{"key":"e_1_2_13_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.05.020"},{"key":"e_1_2_13_58_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.159541"},{"key":"e_1_2_13_59_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200402000-00003"},{"key":"e_1_2_13_60_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.105.008854"},{"key":"e_1_2_13_61_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.05.003"},{"key":"e_1_2_13_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.03.017"},{"key":"e_1_2_13_63_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.38"},{"key":"e_1_2_13_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.09.017"},{"key":"e_1_2_13_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70224-1"},{"key":"e_1_2_13_66_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21287"},{"key":"e_1_2_13_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02653.x"},{"key":"e_1_2_13_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)67788-4"},{"key":"e_1_2_13_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)37157-1"},{"key":"e_1_2_13_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90380-9"},{"key":"e_1_2_13_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)01135-4"},{"key":"e_1_2_13_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81370-7"},{"key":"e_1_2_13_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280234"},{"key":"e_1_2_13_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41917-0"},{"key":"e_1_2_13_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(01)00103-X"},{"key":"e_1_2_13_76_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.23984"},{"key":"e_1_2_13_77_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.5.e70"},{"key":"e_1_2_13_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-006-0062-9"},{"key":"e_1_2_13_79_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.23947"},{"key":"e_1_2_13_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)77221-4"},{"key":"e_1_2_13_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00160-4"},{"key":"e_1_2_13_82_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.3.e32"},{"key":"e_1_2_13_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.8.1209"},{"key":"e_1_2_13_84_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22775"},{"key":"e_1_2_13_85_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.07.042"},{"key":"e_1_2_13_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0398-219"},{"key":"e_1_2_13_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21950"},{"key":"e_1_2_13_88_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21212"},{"key":"e_1_2_13_89_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.27663"},{"key":"e_1_2_13_90_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.058115"},{"key":"e_1_2_13_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201355"},{"key":"e_1_2_13_92_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20285"},{"key":"e_1_2_13_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(03)00286-1"},{"key":"e_1_2_13_94_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807919106"},{"key":"e_1_2_13_95_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290214"},{"key":"e_1_2_13_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"e_1_2_13_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80187-4"},{"key":"e_1_2_13_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00092-7"},{"key":"e_1_2_13_99_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.1999.01143.x"},{"key":"e_1_2_13_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.11.012"},{"key":"e_1_2_13_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80268-6"},{"key":"e_1_2_13_102_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1999.tb02448.x"},{"key":"e_1_2_13_103_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107100"},{"key":"e_1_2_13_104_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(95)90440-9"},{"key":"e_1_2_13_105_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20998"},{"key":"e_1_2_13_106_2","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.34384"},{"key":"e_1_2_13_107_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21686"},{"key":"e_1_2_13_108_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23083"},{"key":"e_1_2_13_109_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1279"},{"key":"e_1_2_13_110_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2330"},{"key":"e_1_2_13_111_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23586"},{"key":"e_1_2_13_112_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119799"},{"key":"e_1_2_13_113_2","first-page":"1237","article-title":"Mice with homozygous disruption of the mdr2 P\u2010glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis","volume":"145","author":"Mauad TH","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_13_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00097-0"},{"key":"e_1_2_13_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80763-1"},{"key":"e_1_2_13_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(98)80013-0"},{"key":"e_1_2_13_117_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1362"},{"key":"e_1_2_13_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00051-4"},{"key":"e_1_2_13_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00050-2"},{"key":"e_1_2_13_120_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011610200"},{"key":"e_1_2_13_121_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308321200"},{"key":"e_1_2_13_122_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0216000"},{"key":"e_1_2_13_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.03.030"},{"key":"e_1_2_13_124_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115479"},{"key":"e_1_2_13_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)33370-8"},{"key":"e_1_2_13_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(69)90078-X"},{"key":"e_1_2_13_127_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1993.tb00737.x"},{"key":"e_1_2_13_128_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106315"},{"key":"e_1_2_13_129_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3963"},{"key":"e_1_2_13_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/83799"},{"key":"e_1_2_13_131_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1771"},{"key":"e_1_2_13_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)41495-6"},{"key":"e_1_2_13_133_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1980.tb00320.x"},{"key":"e_1_2_13_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38259-6"},{"key":"e_1_2_13_135_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.C400004-JLR200"},{"key":"e_1_2_13_136_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.11.859"},{"key":"e_1_2_13_137_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-004-0165-2"},{"key":"e_1_2_13_138_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197602262940907"},{"key":"e_1_2_13_139_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05599.x"},{"key":"e_1_2_13_140_2","first-page":"1392","article-title":"Clinical and molecular genetic analysis of a family with sitosterolemia and co\u2010existing erythrocyte and platelet abnormalities","volume":"91","author":"Su Y","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_13_141_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.027"},{"key":"e_1_2_13_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)34286-3"},{"key":"e_1_2_13_143_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000149140.00499.92"},{"key":"e_1_2_13_144_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606339200"},{"key":"e_1_2_13_145_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050408"},{"key":"e_1_2_13_146_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)30655-5"},{"key":"e_1_2_13_147_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.1.137"},{"key":"e_1_2_13_148_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5252.1126"},{"key":"e_1_2_13_149_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250635"},{"key":"e_1_2_13_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(02)00075-3"},{"key":"e_1_2_13_151_2","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.24.464"},{"key":"e_1_2_13_152_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-195409000-00001"},{"key":"e_1_2_13_153_2","first-page":"147","article-title":"Diagnostic and pathogenetic implications of urinary coproporphyrin excretion in the Dubin\u2013Johnson syndrome","volume":"37","author":"Frank M","year":"1990","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_13_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(98)00044-1"},{"key":"e_1_2_13_155_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.098665"},{"key":"e_1_2_13_156_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.25"},{"key":"e_1_2_13_157_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.038794"},{"key":"e_1_2_13_158_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2940"},{"key":"e_1_2_13_159_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00759.x"},{"key":"e_1_2_13_160_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25279"},{"key":"e_1_2_13_161_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1321"},{"key":"e_1_2_13_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(76)90160-7"},{"key":"e_1_2_13_163_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15665"},{"key":"e_1_2_13_164_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206938"},{"key":"e_1_2_13_165_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.21.7735"},{"key":"e_1_2_13_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.04.024"},{"key":"e_1_2_13_167_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002645"},{"key":"e_1_2_13_168_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.2.695"},{"key":"e_1_2_13_169_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200211150-00014"},{"key":"e_1_2_13_170_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0901-1028"},{"key":"e_1_2_13_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90141-K"},{"key":"e_1_2_13_172_2","first-page":"1926","article-title":"Tissue distribution of P\u2010glycoprotein encoded by a multidrug\u2010resistant gene as revealed by a monoclonal antibody, MRK 16","volume":"48","author":"Sugawara I","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_13_173_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90212-7"},{"key":"e_1_2_13_174_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.1997.0068"},{"key":"e_1_2_13_175_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202607599"},{"key":"e_1_2_13_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.08.007"},{"key":"e_1_2_13_177_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.107.014969"},{"key":"e_1_2_13_178_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.3.1346"},{"key":"e_1_2_13_179_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0090-9556(24)15360-3","article-title":"The role of mdr1a P\u2010glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice","volume":"28","author":"van Asperen J","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_13_180_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.101774"},{"key":"e_1_2_13_181_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135308"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.3019","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.3019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:22:42Z","timestamp":1761049362000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.3019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":180,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1002\/path.3019"],"URL":"https:\/\/doi.org\/10.1002\/path.3019","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"2011-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}