{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:19:35Z","timestamp":1789463975256,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T00:00:00Z","timestamp":1334707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Molecular pathogenesis of high\u2010grade serous ovarian carcinoma (HG\u2010SOC) is poorly understood. Recent recognition of HG\u2010SOC precursor lesions, defined as serous tubal intraepithelial carcinoma (STIC) in fimbria, provides a new venue for the study of early genetic changes in HG\u2010SOC. Using microRNA profiling analysis, we found that\n                    <jats:italic>miR\u2010182<\/jats:italic>\n                    expression was significantly higher in STIC than in matched normal Fallopian tube. Further study revealed that\n                    <jats:italic>miR\u2010182<\/jats:italic>\n                    was significantly overexpressed in most HG\u2010SOC cases. To test whether\n                    <jats:italic>miR\u2010182<\/jats:italic>\n                    plays a major role in early tumourigenesis of HG\u2010SOC, we overexpressed\n                    <jats:italic>miR\u2010182<\/jats:italic>\n                    in immortalized ovarian surface, Fallopian tube secretory cells and malignant ovarian cell lines, and found that\n                    <jats:italic>miR\u2010182<\/jats:italic>\n                    overexpression resulted in increased tumour transformation\n                    <jats:italic>in vitro<\/jats:italic>\n                    , and enhanced tumour invasiveness\n                    <jats:italic>in vitro<\/jats:italic>\n                    and metastasis\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Mechanistically, we demonstrated that the oncogenic properties of\n                    <jats:italic>miR\u2010182<\/jats:italic>\n                    in ovarian cancer were mediated in part by its impaired repair of DNA double\u2010strand breaks and negative regulation of\n                    <jats:italic>breast cancer 1<\/jats:italic>\n                    (\n                    <jats:italic>BRCA1<\/jats:italic>\n                    ) and\n                    <jats:italic>metastasis suppressor 1<\/jats:italic>\n                    (\n                    <jats:italic>MTSS1<\/jats:italic>\n                    ) expression as well as its positive regulation of the oncogene\n                    <jats:italic>high\u2010mobility group AT\u2010hook 2<\/jats:italic>\n                    (\n                    <jats:italic>HMGA2<\/jats:italic>\n                    ). Our findings suggest that\n                    <jats:italic>miR\u2010182<\/jats:italic>\n                    dysregulation confers powerful oncogenic potential in the tumourigenesis of HG\u2010SOC. Copyright \u00a9 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.4000","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T08:16:23Z","timestamp":1328775383000},"page":"204-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["<i>MiR\u2010182<\/i>\n                    overexpression in tumourigenesis of high\u2010grade serous ovarian carcinoma"],"prefix":"10.1002","volume":"228","author":[{"given":"Zhaojian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel 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