{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:23:58Z","timestamp":1789691038020,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T00:00:00Z","timestamp":1337731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"Abstract<\/jats:title>\n \n Crim1<\/jats:italic>\n hypomorphic (\n Crim1<\/jats:italic>\n \n $^{KST264\/KST264}$\n \n <\/jats:styled-content>\n ) mice display progressive renal disease characterized by glomerular defects, leaky peritubular vasculature, and progressive interstitial fibrosis. Here we show that 27% of these mice also present with hydronephrosis, suggesting obstructive nephropathy. Dynamic magnetic resonance imaging using Magnevist showed fast development of hypo\u2010intense signal in the kidneys of\n Crim1<\/jats:italic>\n \n $^{KST264\/KST264}$\n \n <\/jats:styled-content>\n mice, suggesting pooling of filtrate within the renal parenchyma. Rhodamine dextran (10 kDa) clearance was also delayed in\n Crim1<\/jats:italic>\n \n $^{KST264\/KST264}$\n \n <\/jats:styled-content>\n mice. Pyeloureteric peristalsis, while present, was less co\u2010ordinated in\n Crim1<\/jats:italic>\n \n $^{KST264\/KST264}$\n \n <\/jats:styled-content>\n mice. However, isolated renal pelvis preparations suggest normal pelvic smooth muscle contractile responses. An analysis of maturation during the immediate postnatal period [postnatal day (P) 0\u201015] revealed defects in papillary extension in\n Crim1<\/jats:italic>\n \n $^{KST264\/KST264}$\n \n <\/jats:styled-content>\n mice. While\n Crim1<\/jats:italic>\n expression is weak in pelvic smooth muscle, strong expression is seen in the interstitium and loops of Henle of the extending papilla, commencing at the tip of the P1 papilla and disseminating throughout the papilla by P15. These results, as well as implicating Crim1 in papillary extension and pelvic smooth muscle contractility, highlight the previously unrecognized association between defects in papillary development and progression to chronic kidney disease later in life. Copyright \u00a9 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.\n <\/jats:p>","DOI":"10.1002\/path.4036","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T12:17:56Z","timestamp":1333541876000},"page":"499-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between congenital defects in papillary outgrowth and functional obstruction in\n Crim1<\/i>\n mutant mice"],"prefix":"10.1002","volume":"227","author":[{"given":"Lorine","family":"Wilkinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyoman D","family":"Kurniawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Leng","family":"Phua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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