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The\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    , traditionally viewed as the structural elements within which cells reside, is actually a functional tissue whose components possess not only scaffolding characteristics, but also growth factor, mitogenic, and other bioactive properties. Although it has been suggested that tissue fibrosis simply reflects an \u2018exuberant\u2019 wound\u2010healing response, examination of the\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    and the roles of myofibroblasts during fibrogenesis instead suggest that the organism may be attempting to recapitulate developmental programmes designed to regenerate functional tissue. Evidence of this is provided by the temporospatial re\u2010emergence of embryonic\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    proteins by fibroblasts and myofibroblasts that induce cellular programmatic responses intended to produce a functional tissue. In the setting of wound healing (or physiological fibrosis), this occurs in a highly regulated and exquisitely choreographed fashion which results in cessation of haemorrhage, restoration of barrier integrity, and re\u2010establishment of tissue function. However, pathological tissue fibrosis, which oftentimes causes organ dysfunction and significant morbidity or mortality, likely results from dysregulation of normal wound\u2010healing processes or abnormalities of the process itself. This review will focus on the myofibroblast\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    and its role in both physiological and pathological fibrosis, and will discuss the potential for therapeutically targeting\n                    <jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>\n                    proteins for treatment of fibrotic disorders.\n                  <\/jats:p>","DOI":"10.1002\/path.4104","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T06:13:10Z","timestamp":1348207990000},"page":"298-309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":748,"title":["The myofibroblast matrix: implications for tissue repair and\u00a0fibrosis"],"prefix":"10.1002","volume":"229","author":[{"given":"Franco","family":"Klingberg","sequence":"first","affiliation":[{"name":"Laboratory of Tissue Repair and Regeneration Matrix Dynamics Group, Faculty of Dentistry, University of Toronto  Toronto Ontario M5S 3E2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Hinz","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Repair and Regeneration Matrix Dynamics Group, Faculty of Dentistry, University of Toronto  Toronto Ontario M5S 3E2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S","family":"White","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine University of Michigan  1150 W Medical Center Drive, 6301 MSRB III SPC5642 Ann Arbor MI 48109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.02.004"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700613"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.081170"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092217"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110551"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130246"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.06.011"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.07002.x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2011.00764.x"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.74"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385940-2.00007-3"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283524b9a"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31139"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00758.x"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.199"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.02.038"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22322"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23925"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.20377"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.070112"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23405"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.075"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-011-9340-x"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.05.002"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2010.03.004"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-4-2"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700654"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.231548"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090517"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080433"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.07.001"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030563"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-012110-142225"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399410001481"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.77"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-394305-7.00004-5"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.06.001"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3562"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1533\/9781845697792.39"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411001967"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2011.05.004"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.04.033"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.3410\/B2-78"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9093-y"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328356800f"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-3-8"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2568"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.023820"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201109041"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e10-03-0251"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00466.x"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171643"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.08.015"},{"key":"e_1_2_14_56_1","doi-asserted-by":"p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