{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:23Z","timestamp":1791288923898,"version":"4.3.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T00:00:00Z","timestamp":1359072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>\n                      Mucinous carcinomas represent a distinct morphological subtype which can arise from several organ sites, including the ovary, and their genetic characteristics are largely under\u2010described. Exome sequencing of 12 primary mucinous ovarian tumours identified\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">RNF43<\/jats:styled-content>\n                      <\/jats:italic>\n                      as the most frequently somatically mutated novel gene, secondary to\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">KRAS<\/jats:styled-content>\n                      <\/jats:italic>\n                      and mutated at a frequency equal to that of\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">TP53<\/jats:styled-content>\n                      <\/jats:italic>\n                      and\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\n                      <\/jats:italic>\n                      . Further screening of\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">RNF43<\/jats:styled-content>\n                      <\/jats:italic>\n                      in a larger cohort of ovarian tumours identified additional mutations, with a total frequency of 2\/22 (9%) in mucinous ovarian borderline tumours and 6\/29 (21%) in mucinous ovarian carcinomas. Seven mutations were predicted to truncate the protein and one missense mutation was predicted to be deleterious by\n                      <jats:italic>in silico<\/jats:italic>\n                      analysis. Six tumours had allelic imbalance at the\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">RNF43<\/jats:styled-content>\n                      <\/jats:italic>\n                      locus, with loss of the wild\u2010type allele. The mutation spectrum strongly suggests that\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">RNF43<\/jats:styled-content>\n                      <\/jats:italic>\n                      is an important tumour suppressor gene in mucinous ovarian tumours, similar to its reported role in mucinous pancreatic precancerous cysts. Copyright \u00a9 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                    <\/jats:bold>\n                  <\/jats:p>","DOI":"10.1002\/path.4134","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T04:22:41Z","timestamp":1351052561000},"page":"469-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["<i>\n                      <scp>RNF43<\/scp>\n                    <\/i>\n                    is a tumour suppressor gene mutated in mucinous tumours of the ovary"],"prefix":"10.1002","volume":"229","author":[{"given":"Georgina L","family":"Ryland","sequence":"first","affiliation":[{"name":"Victorian Breast Cancer Research Consortium (VBCRC), Cancer Genetics Laboratory Peter MacCallum Cancer Centre  East Melbourne Victoria Australia"},{"name":"Centre for Cancer Research, Monash Institute of Medical Research Monash University  Clayton Victoria 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