{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:45Z","timestamp":1761006945689,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Type 1 diabetes (<jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content>) is caused by the destruction of insulin\u2010producing pancreatic <jats:italic>\u03b2<\/jats:italic> cells by the patient's immune system. While the underlying genetics and immunopathology are fairly well characterized, the environmental trigger remains unidentified. Numerous studies have centred on the role of enteroviruses as aetiological factors that could initiate or accelerate <jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content> development. The most convincing evidence to date consists of an array of reports documenting the presence of enteroviral nucleic acids in peripheral blood at diagnosis. A prominent hypothesis is that enteroviruses may infect the pancreatic islets and thus be responsible for the islet\u2010specific up\u2010regulation of <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> class I that is commonly observed, possibly enabling T cell recognition and cytotoxicity. Past immunohistochemical studies have indeed shown that antibodies binding the enteroviral capsid protein <jats:styled-content style=\"fixed-case\">VP1<\/jats:styled-content> preferentially stain the pancreatic <jats:italic>\u03b2<\/jats:italic> cells from diabetic individuals. New data now indicate that the <jats:styled-content style=\"fixed-case\">VP1<\/jats:styled-content> antibody used in these studies cross\u2010reacts with mitochondrial proteins. Copyright \u00a9 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:bold><\/jats:p>","DOI":"10.1002\/path.4174","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T13:39:31Z","timestamp":1360157971000},"page":"1-3","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antibody cross\u2010reactivity and the viral aetiology of type 1 diabetes"],"prefix":"10.1002","volume":"230","author":[{"given":"Ken T.","family":"Coppieters","sequence":"first","affiliation":[{"name":"Type 1 Diabetes R&amp;D Center Novo Nordisk Inc.  Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"von Herrath","sequence":"additional","affiliation":[{"name":"Type 1 Diabetes R&amp;D Center Novo Nordisk Inc.  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