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This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression\u2010based stratification. These parameters rely on tumour\u2010cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the\n                      <jats:italic>in situ<\/jats:italic>\n                      immune cell infiltrate in tumours. A methodology named \u2018Immunoscore\u2019 has been defined to quantify the\n                      <jats:italic>in situ<\/jats:italic>\n                      immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current\n                      <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">UICC TNM<\/jats:styled-content>\n                      classification, since it has been demonstrated to be a prognostic factor superior to the\n                      <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content>\n                      \/\n                      <jats:styled-content style=\"fixed-case\">UICC TNM<\/jats:styled-content>\n                      classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated\n                      <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content>\n                      \u2010I (\n                      <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content>\n                      \u2010Immune). \u00a9 2013 The Authors.\n                      <jats:italic>Journal of Pathology<\/jats:italic>\n                      published by John Wiley &amp; Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.\n                    <\/jats:bold>\n                  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