{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:37:52Z","timestamp":1778895472799,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T00:00:00Z","timestamp":1402876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"a grant-in-aid for research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan","award":["24390094; 221S0001-04; 24108001"],"award-info":[{"award-number":["24390094; 221S0001-04; 24108001"]}]},{"name":"the National Cancer Center Research and Development Fund (Japan)","award":["25-A-5"],"award-info":[{"award-number":["25-A-5"]}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Due to the formerly widespread use of asbestos, malignant mesothelioma (MM<\/jats:styled-content>) is increasingly frequent worldwide. MM<\/jats:styled-content> is classified into epithelioid (EM<\/jats:styled-content>), sarcomatoid (SM<\/jats:styled-content>), and biphasic subtypes. SM<\/jats:styled-content> is less common than EM<\/jats:styled-content> but is recognized as the most aggressive type of MM<\/jats:styled-content>, and these patients have a poor prognosis. To identify genes responsible for the aggressiveness of SM<\/jats:styled-content>, we induced EM<\/jats:styled-content> and SM<\/jats:styled-content> in rats, using asbestos, and compared their transcriptomes. Based on the results, we focused on connective tissue growth factor (Ctgf<\/jats:italic>), whose expression was significantly increased in SM<\/jats:styled-content> compared with EM<\/jats:styled-content>; EM<\/jats:styled-content> itself exhibited an increased expression of Ctgf<\/jats:italic> compared with normal mesothelium. Particularly in SM<\/jats:styled-content>, Ctgf was a major regulator of MM<\/jats:styled-content> proliferation and invasion through activation of the \u03b2<\/jats:italic>\u2010catenin\u2013TCF\u2013LEF<\/jats:styled-content> signalling pathway, which is autocrine and formed a positive feedback loop via LRP6<\/jats:styled-content> as a receptor for secreted Ctgf. High Ctgf<\/jats:italic> expression also played a role in the epithelial\u2013mesenchymal transition in MM<\/jats:styled-content>. Furthermore, Ctgf is a novel serum biomarker for both early diagnosis and determining the MM<\/jats:styled-content> prognosis in rats. These data link Ctgf to SM<\/jats:styled-content> through the LRP6\u2013GSK3<\/jats:styled-content>\u03b2\u2013\u03b2<\/jats:italic>\u2010catenin\u2013TCF<\/jats:styled-content>\u2013Ctgf autocrine axis and suggest Ctgf as a therapeutic target. Copyright \u00a9 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4377","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T10:02:43Z","timestamp":1400493763000},"page":"402-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Connective tissue growth factor and \u03b2<\/i>\u2010catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma"],"prefix":"10.1002","volume":"233","author":[{"given":"Li","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoriko","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine 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