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Although not completely understood, the pathophysiology of the disease involves chronic dysregulation of inflammatory and vascular signalling. In the quest for novel therapeutic targets, we investigated the involvement of galectin\u20101 (Gal\u20101), an endogenous glycan\u2010binding protein endowed with both immunosuppressive and pro\u2010angiogenic activities, in the pathophysiology of endometriotic lesions. Here we show that Gal\u20101 is selectively expressed in stromal and endothelial cells of human endometriotic lesions. Using an experimental endometriosis model induced in wild\u2010type and Gal\u20101\u2010deficient (<jats:italic>Lgals1<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic>) mice, we showed that this lectin orchestrates the formation of vascular networks in endometriotic lesions <jats:italic>in vivo<\/jats:italic>, facilitating their ectopic growth independently of vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) and the keratinocyte\u2010derived <jats:styled-content style=\"fixed-case\">CXC<\/jats:styled-content>\u2010motif (<jats:styled-content style=\"fixed-case\">CXC\u2010KC<\/jats:styled-content>) chemokine. Targeting Gal\u20101 using a specific neutralizing <jats:styled-content style=\"fixed-case\">mAb<\/jats:styled-content> reduced the size and vascularized area of endometriotic lesions within the peritoneal compartment. These results underline the essential role of Gal\u20101 during endometriosis and validate this lectin as a possible target for the treatment of disease. Copyright \u00a9 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4397","type":"journal-article","created":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T22:51:27Z","timestamp":1404168687000},"page":"329-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Targeting galectin\u20101\u2010induced angiogenesis mitigates the severity of endometriosis"],"prefix":"10.1002","volume":"234","author":[{"given":"Juan I","family":"Bast\u00f3n","sequence":"first","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Endometrial Instituto de Biolog\u00eda y Medicina Experimental \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (IBYME\u2010CONICET)  Vuelta de Obligado 2490 Buenos Aires (C1428ADN) Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa I","family":"Bara\u00f1ao","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda de la Reproducci\u00f3n Instituto de Biolog\u00eda y Medicina Experimental \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (IBYME\u2010CONICET)  Vuelta de Obligado 2490 Buenos Aires (C1428ADN) Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anal\u00eda G","family":"Ricci","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda de la Reproducci\u00f3n Instituto de Biolog\u00eda y Medicina Experimental \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (IBYME\u2010CONICET)  Vuelta de Obligado 2490 Buenos Aires (C1428ADN) Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela A","family":"Bilotas","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunolog\u00eda de la Reproducci\u00f3n Instituto de Biolog\u00eda y Medicina Experimental \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (IBYME\u2010CONICET)  Vuelta de Obligado 2490 Buenos Aires (C1428ADN) Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla N","family":"Olivares","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Endometrial Instituto de Biolog\u00eda y Medicina Experimental \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (IBYME\u2010CONICET)  Vuelta de Obligado 2490 Buenos Aires (C1428ADN) Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 J","family":"Singla","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas \u2018Jos\u00e9 de San Mart\u00edn\u2019  Av. C\u00f3rdoba 2351 Buenos Aires (C1120AAR) Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro M","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Hospital Naval de Buenos Aires \u2018Cirujano Mayor Dr. Pedro Mallo\u2019  Patricias Argentinas 351 Buenos Aires (C1405BWD) Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C","family":"Stupirski","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunopatolog\u00eda Instituto de Biolog\u00eda y Medicina Experimental \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (IBYME\u2010CONICET)  Vuelta de Obligado 2490 Buenos Aires (C1428ADN) Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego O","family":"Croci","sequence":"additional","affiliation":[{"name":"Laboratorio de Inmunopatolog\u00eda Instituto de Biolog\u00eda y Medicina Experimental \u2013 Consejo Nacional de Investigaciones 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