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Because <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> persists in the B cells of the asymptomatic host, it can easily be envisaged how it contributes to the development of B\u2010cell lymphomas. However, <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> is also found in other cancers, including T\u2010cell\/natural killer cell lymphomas and several epithelial malignancies. Explaining the aetiological role of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> is challenging, partly because the virus probably contributes differently to each tumour and partly because the available disease models cannot adequately recapitulate the subtle variations in the virus\u2013host balance that exist between the different <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010associated cancers. A further challenge is to identify the co\u2010factors involved; because most persistently infected individuals will never develop an <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010associated cancer, the virus cannot be working alone. This article will review what is known about the contribution of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> to lymphoma development. Copyright \u00a9 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4459","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T03:41:43Z","timestamp":1412739703000},"page":"312-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":207,"title":["The Epstein\u2013Barr virus and the pathogenesis of lymphoma"],"prefix":"10.1002","volume":"235","author":[{"given":"Martina","family":"Vockerodt","sequence":"first","affiliation":[{"name":"Centre for Human Virology and the School of Cancer Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-3607","authenticated-orcid":false,"given":"Lee\u2010Fah","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Oral Biology and Biomedical Sciences &amp; Oral Cancer Research and Coordinating Centre, Faculty of Dentistry University of Malaya  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