{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:06:52Z","timestamp":1792782412823,"version":"4.5.0"},"reference-count":73,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,11]],"date-time":"2014-12-11T00:00:00Z","timestamp":1418256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI103617"],"award-info":[{"award-number":["AI103617"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of North Carolina University Research Award"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Infants and young children with acute onset of wheezing and reduced respiratory airflows are often diagnosed with obstruction and inflammation of the small bronchiolar airways, ie bronchiolitis. The most common aetological agents causing bronchiolitis in young children are the respiratory viruses, and of the commonly encountered respiratory viruses, respiratory syncytial virus (\n                    <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                    ) has a propensity for causing bronchiolitis. Indeed,\n                    <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                    bronchiolitis remains the major reason why previously healthy infants are admitted to hospital. Why\n                    <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                    infection is such a predominant cause of bronchiolitis is the subject of this review. By reviewing the available histopathology of\n                    <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                    bronchiolitis, both in humans and relevant animal models, we identify hallmark features of\n                    <jats:styled-content style=\"fixed-case\">RSV<\/jats:styled-content>\n                    infection of the distal airways and focus attention on the consequences of columnar cell cytopathology occurring in the bronchioles, which directly impacts the development of bronchiolar obstruction, inflammation and disease. Copyright \u00a9 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.4462","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T03:48:20Z","timestamp":1412912900000},"page":"266-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":155,"title":["Respiratory syncytial virus (\n                    <scp>RSV<\/scp>\n                    ) and its propensity for causing bronchiolitis"],"prefix":"10.1002","volume":"235","author":[{"given":"Raymond J","family":"Pickles","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology University of North Carolina  Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"DeVincenzo","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Microbiology, Immunology and Biochemistry, Division of Infectious Diseases University of Tennessee School of Medicine, and Molecular Diagnostics and Virology Laboratories, Le Bonheur Children's Hospital  Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115243"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204630"},{"key":"e_1_2_10_4_1","first-page":"543","article-title":"Risk of primary infection and reinfection with respiratory syncytial virus","volume":"140","author":"Glezen WP","year":"1986","journal-title":"Am J Dis Child"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2003.00056.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804877"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60206-1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.15.1440"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/317655"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.179"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.6.1717"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.23.1.7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0507"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1529-y"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-3074"},{"key":"e_1_2_10_16_1","volume-title":"Field's Virology","author":"Collins PL","year":"2001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu327"},{"key":"e_1_2_10_18_1","first-page":"291","article-title":"Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA) II. 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