{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:51:56Z","timestamp":1789707116956,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000537","name":"Breakthrough Breast Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok","doi-asserted-by":"publisher","award":["K109626, K108465, K84173"],"award-info":[{"award-number":["K109626, K108465, K84173"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"name":"eureka","award":["HU_12-1-2012-0057"],"award-info":[{"award-number":["HU_12-1-2012-0057"]}]},{"name":"KTIA AIK","award":["12-1-2013-0041"],"award-info":[{"award-number":["12-1-2013-0041"]}]},{"name":"NIHR Royal Marsden\/Institute of Cancer Research Biomedical Research Centre"},{"name":"T\u00c3\u0081MOP","award":["4.2.4.A\/1-11-1-2012-0001"],"award-info":[{"award-number":["4.2.4.A\/1-11-1-2012-0001"]}]},{"name":"Vienna Fund for Innovative Interdisciplinary Cancer Research","award":["AP00543OFF"],"award-info":[{"award-number":["AP00543OFF"]}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The appearance of lung metastases is associated with poor outcome and the management of patients with secondary pulmonary tumours remains a clinical challenge. We examined the vascularization process of lung metastasis in six different preclinical models and found that the tumours incorporated the pre\u2010existing alveolar capillaries (ie vessel co\u2010option). During the initial phase of vessel co\u2010option, the incorporated capillaries were still sheathed by pneumocytes, but these incorporated vessels subsequently underwent different fates dependent on the model. In five of the models examined (\n                    <jats:styled-content style=\"fixed-case\">B16<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">HT1080<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">HT25<\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">C26<\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">MAT<\/jats:styled-content>\n                    B\u2010\n                    <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                    ), the tumour cells gradually stripped the pneumocytes from the vessels. These dissected pneumocytes underwent fragmentation, but the incorporated microvessels survived. In the sixth model (\n                    <jats:styled-content style=\"fixed-case\">C38<\/jats:styled-content>\n                    ), the tumour cells failed to invade the alveolar walls. Instead, they induced the development of vascularized desmoplastic tissue columns. Finally, we examined the process of arterialization in lung metastases and found that they became arterialized when their diameter grew to exceed 5\u2009mm. In conclusion, our data show that lung metastases can vascularize by co\u2010opting the pulmonary microvasculature. This is likely to have important clinical implications, especially with respect to anti\u2010angiogenic therapies. Copyright \u00a9 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n.\n                  <\/jats:p>","DOI":"10.1002\/path.4464","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T03:27:26Z","timestamp":1413430046000},"page":"384-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Mechanism of tumour vascularization in experimental lung metastases"],"prefix":"10.1002","volume":"235","author":[{"given":"Vanessza","family":"Szabo","sequence":"first","affiliation":[{"name":"1st Department of Pathology and Experimental Cancer Research Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina","family":"Bugyik","sequence":"additional","affiliation":[{"name":"1st Department of Pathology and Experimental Cancer Research Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Dezso","sequence":"additional","affiliation":[{"name":"1st Department of Pathology and Experimental Cancer Research Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Ecker","sequence":"additional","affiliation":[{"name":"1st Department of Pathology and Experimental Cancer Research Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nagy","sequence":"additional","affiliation":[{"name":"1st Department of Pathology and Experimental Cancer Research Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozsef","family":"Timar","sequence":"additional","affiliation":[{"name":"Tumor Progression Research Group Hungarian Academy of Sciences\u2013Semmelweis University  Budapest Hungary"},{"name":"2nd Department of Pathology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozsef","family":"Tovari","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology National Institute of Oncology  Budapest Hungary"},{"name":"Department of Thoracic Surgery Semmelweis University\u2013National Institute of Oncology  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Laszlo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria L","family":"Bridgeman","sequence":"additional","affiliation":[{"name":"Tumour Biology Team, Breakthrough Breast Cancer Research Centre The Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Wan","sequence":"additional","affiliation":[{"name":"Tumour Biology Team, Breakthrough Breast Cancer Research Centre The Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Frentzas","sequence":"additional","affiliation":[{"name":"Tumour Biology Team, Breakthrough Breast Cancer Research Centre The Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"Tumour Biology Team, Breakthrough Breast Cancer Research Centre The Institute of Cancer Research  London UK"},{"name":"Translational Cancer Research Unit GZA Hospitals Sint\u2010Augustinus  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Tumour Biology Team, Breakthrough Breast Cancer Research Centre The Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balazs","family":"Dome","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Semmelweis University\u2013National Institute of Oncology  Budapest Hungary"},{"name":"Department of Thoracic Surgery Medical University of Vienna  Austria"},{"name":"National Koranyi Institute of Pulmonology  Budapest Hungary"},{"name":"Department of Biomedical Imaging and Image\u2010guided Therapy Medical University of Vienna  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandor","family":"Paku","sequence":"additional","affiliation":[{"name":"1st Department of Pathology and Experimental Cancer Research Semmelweis University  Budapest Hungary"},{"name":"Tumor Progression Research Group Hungarian Academy of Sciences\u2013Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2005.12.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1052-3359(25)00313-8","article-title":"Imaging characteristics of metastatic disease to the chest","volume":"8","author":"Snyder BJ","year":"1998","journal-title":"Chest Surg Clin N Am"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.180.1.2052672"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810601)47:11<2595::AID-CNCR2820471114>3.0.CO;2-Q"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt288"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70397-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425240903167926"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2010.06.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1342959"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060302"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1893"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1275"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.09.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.21"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-014-9420-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197111182852108"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.1.4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.133.2.275"},{"key":"e_1_2_7_20_1","first-page":"1417","article-title":"Non\u2010small\u2010cell lung carcinoma tumor growth without morphological evidence of neo\u2010angiogenesis","volume":"151","author":"Pezzella F","year":"1997","journal-title":"Am J Pathol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(96)00377-2"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603039"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02268-6"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.11.008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02800.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.105"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64521-X"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000140373"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090095"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.6.655"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65173-5"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.05.033"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2008.06.009"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1124"},{"key":"e_1_2_7_36_1","first-page":"6791","article-title":"Glomeruloid microvascular proliferation is superior to intratumoral microvessel density as a prognostic marker in non\u2010small cell lung cancer","volume":"63","author":"Tanaka F","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-535"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092280107"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092160207"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9399-9"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1971.00310170055006"},{"key":"e_1_2_7_42_1","first-page":"13","article-title":"The architecture of the alveolar wall: an ultrastructural study in man","volume":"12","author":"Rosario EJ","year":"1973","journal-title":"Cardiovasc Res Cent Bull"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0271fje"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20886"},{"key":"e_1_2_7_45_1","volume-title":"The Human Lung","author":"Hv Hayek","year":"1960"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092430310"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(96)80035-X"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1988.207"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1968.34"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/IMI.0b013e31820b1e63"},{"key":"e_1_2_7_51_1","first-page":"669","article-title":"Ultrastructural studies on the lung colonization by nonmetastatic rat tumor cells","volume":"6","author":"Knierim M","year":"1986","journal-title":"Anticancer Res"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01580408"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011858925376"},{"key":"e_1_2_7_54_1","first-page":"957","article-title":"Ultrastructural analysis of experimentally induced invasion in the rat lung by tumor cells metastasizing lymphatically","volume":"6","author":"Paku S","year":"1986","journal-title":"Anticancer Res"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428501"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4464","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.4464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:05:53Z","timestamp":1760958353000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.4464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,18]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1002\/path.4464"],"URL":"https:\/\/doi.org\/10.1002\/path.4464","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,18]]},"assertion":[{"value":"2014-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}