{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:42:14Z","timestamp":1769265734724,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T00:00:00Z","timestamp":1420675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015153","name":"Fondation Air Liquide","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015153","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>Intra\u2010uterine growth restriction (IUGR<\/jats:styled-content>) dramatically increases the risk of bronchopulmonary dysplasia in preterm babies, a disease characterized by arrested alveolarization and abnormal microvascular angiogenesis. We have previously described a rodent low protein diet (LPD<\/jats:styled-content>) model of IUGR<\/jats:styled-content> inducing impaired alveolarization, but failed to demonstrate any modification of the classical factors involved in lung development. We performed a genome\u2010wide microarray analysis in 120 rat pups with LPD<\/jats:styled-content>\u2010induced IUGR<\/jats:styled-content> and their controls, at three key time points of the alveolarization process: postnatal day 4 (P4<\/jats:styled-content>): start of alveolarization; P10<\/jats:styled-content>: peak of the alveolarization process and P21<\/jats:styled-content>: end of the alveolarization process. Results were analysed using Arraymining, DAVID<\/jats:styled-content> and KEGG<\/jats:styled-content> software and validated by qRT\u2013PCR<\/jats:styled-content> and western blots. Considering a cut\u2010off of 2:1 as significant, 67 transcripts at P4<\/jats:styled-content>, 102 transcripts at P10<\/jats:styled-content> and 451 transcripts at P21<\/jats:styled-content> were up\u2010regulated, and 89 transcripts at P4<\/jats:styled-content>, 25 transcripts at P10<\/jats:styled-content> and 585 transcripts at P21<\/jats:styled-content> were down\u2010regulated. Automatic functional classification identified three main modified pathways, 'cell adhesion molecules', 'cardiac muscle contraction' and 'peroxisome proliferator\u2010activated receptor' (PPAR<\/jats:styled-content>). Protein analysis confirmed involvement of the PPAR<\/jats:styled-content> pathway, with an increase of FABP4<\/jats:styled-content>, an activator of this pathway, at P4<\/jats:styled-content> and an increase of adiponectin at P21<\/jats:styled-content>. Other data also suggest involvement of the PPAR<\/jats:styled-content> pathway in impaired alveolarization. Our results show that deregulation of the PPAR<\/jats:styled-content> pathway may be an important component of the mechanism inducing impaired alveolarization observed in IUGR<\/jats:styled-content>. The complete dataset is available as GEO<\/jats:styled-content> profiles on the Gene Expression Omnibus (GEO<\/jats:styled-content>) database (\nwww.ncbi.nih.gov\/geo\/<\/jats:ext-link>, GEO<\/jats:styled-content> Accession No. GSE56956<\/jats:styled-content>). Copyright \u00a9 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4470","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T05:13:47Z","timestamp":1414473227000},"page":"420-430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Impaired alveolarization and intra\u2010uterine growth restriction in rats: a postnatal genome\u2010wide analysis"],"prefix":"10.1002","volume":"235","author":[{"given":"E","family":"Zana\u2010Taieb","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Descartes Paris France"},{"name":"Fondation PremUp, 53 avenue de l'Observatoire, 75014 Paris France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1141 Paris France"},{"name":"Assistance Publique \u2010 H\u00f4pitaux de Paris, Service de M\u00e9decine et R\u00e9animation N\u00e9onatales de Port\u2010Royal, Groupe Hospitalier Cochin, Broca, H\u00f4tel\u2010Dieu, 53 Avenue de l'Observatoire, 75014 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Pham","sequence":"additional","affiliation":[{"name":"Fondation PremUp, 53 avenue de l'Observatoire, 75014 Paris France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1141 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ML","family":"Franco\u2010Montoya","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U955 IMRB Equipe 04, Facult\u00e9 de M\u00e9decine de Cr\u00e9teil, 94010 Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Jacques","sequence":"additional","affiliation":[{"name":"Genom'ic, INSERM U1016, CNRS UMR8104, Paris 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