{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:04:52Z","timestamp":1787580292062,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>Human skin colour, ie pigmentation, differs widely among individuals, as do their responses to various types of ultraviolet radiation (UV<\/jats:styled-content>) and their risks of skin cancer. In some individuals, UV<\/jats:styled-content>\u2010induced pigmentation persists for months to years in a phenomenon termed long\u2010lasting pigmentation (LLP<\/jats:styled-content>). It is unclear whether LLP<\/jats:styled-content> is an indicator of potential risk for skin cancer. LLP<\/jats:styled-content> seems to have similar features to other forms of hyperpigmentation, eg solar lentigines or age spots, which are clinical markers of photodamage and risk factors for precancerous lesions. To investigate what UV<\/jats:styled-content>\u2010induced molecular changes may persist in individuals with LLP<\/jats:styled-content>, clinical specimens from non\u2010sunburn\u2010inducing repeated UV<\/jats:styled-content> exposures (UVA<\/jats:styled-content>, UVB<\/jats:styled-content> or UVA<\/jats:styled-content> + UVB<\/jats:styled-content>) at 4 months post\u2010exposure (short\u2010term LLP<\/jats:styled-content>) were evaluated by microarray analysis and dataset mining. Validated targets were further evaluated in clinical specimens from six healthy individuals (three LLP<\/jats:styled-content>+ and three LLP<\/jats:styled-content>\u2212) followed for more than 9 months (long\u2010term LLP<\/jats:styled-content>) who initially received a single sunburn\u2010inducing UVA<\/jats:styled-content> + UVB<\/jats:styled-content> exposure. The results support a UV<\/jats:styled-content>\u2010induced hyperpigmentation model in which basal keratinocytes have an impaired ability to remove melanin that leads to a compensatory mechanism by neighbouring keratinocytes with increased proliferative capacity to maintain skin homeostasis. The attenuated expression of SOX7<\/jats:styled-content> and other hemidesmosomal components (integrin \u03b16\u03b24 and plectin) leads to increased melanosome uptake by keratinocytes and points to a spatial regulation within the epidermis. The reduced density of hemidesmosomes provides supporting evidence for plasticity at the epidermal\u2013dermal junction. Altered hemidesmosome plasticity, and the sustained nature of LLP<\/jats:styled-content>, may be mediated by the role of SOX7<\/jats:styled-content> in basal keratinocytes. The long\u2010term sustained subtle changes detected are modest, but sufficient to create dramatic visual differences in skin colour. These results suggest that the hyperpigmentation phenomenon leading to increased interdigitation develops in order to maintain normal skin homeostasis in individuals with LLP<\/jats:styled-content>. Copyright \u00a9 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4497","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T12:27:38Z","timestamp":1418128058000},"page":"17-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["UV<\/scp> exposure modulates hemidesmosome plasticity, contributing to long\u2010term pigmentation in human skin"],"prefix":"10.1002","volume":"236","author":[{"given":"Sergio G","family":"Coelho","sequence":"first","affiliation":[{"name":"Laboratory of Cell Biology National Cancer Institute, National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C","family":"Valencia","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology National Cancer Institute, National Institutes of Health Bethesda MD 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