{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:29:37Z","timestamp":1793964577488,"version":"4.8.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T00:00:00Z","timestamp":1432771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000301","name":"Breast Cancer Campaign","doi-asserted-by":"publisher","award":["2011MaySF01"],"award-info":[{"award-number":["2011MaySF01"]}],"id":[{"id":"10.13039\/501100000301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Breast cancer is known to display considerable inter\u2010 and intra\u2010tumour genetic heterogeneity. It is now widely accepted that no two breast cancers harbour the same complement of genomic alterations, and that both primary and metastatic breast cancers are composed of multiple genetically diverse subclones that evolve under different selective pressures. Recent work published in the <jats:italic>Journal of Pathology<\/jats:italic> by Desmedt and colleagues questions the evolutionary dynamics of multi\u2010focal breast cancer with similar pathological features by studying the mutational repertoire of different lesions. Whilst the majority of the lesions showed some common driver alterations, one\u2010third lacked any common mutations, suggesting very early clonal divergence. These and other recent observations underscore the need for a fundamental understanding of the rules governing breast cancer evolution, and highlight the need for in\u2010depth assessment of driver alterations for appropriate patient management and selective treatment. Copyright \u00a9 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4557","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T10:14:50Z","timestamp":1430993690000},"page":"1-3","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Breast cancer heterogeneity: parallel evolution or conscious uncoupling?"],"prefix":"10.1002","volume":"237","author":[{"given":"Rachael C","family":"Natrajan","sequence":"first","affiliation":[{"name":"Breakthrough Breast Cancer Research Centre and Department of Molecular Pathology Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11412"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0349"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113205"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.04.023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10933"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4540"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2762"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08645"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13600"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2822"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13556"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu239"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4557","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.4557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:29:02Z","timestamp":1760952542000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.4557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,28]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1002\/path.4557"],"URL":"https:\/\/doi.org\/10.1002\/path.4557","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,28]]},"assertion":[{"value":"2015-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}