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Accordingly, a genome\u2010wide expression array analysis was performed on MPM<\/jats:styled-content> cell lines and a set of 139 genes was identified as differentially expressed in cells with high versus low migratory activity. Reduced expression of the novel tumour suppressor integrin \u03b17<\/jats:italic> (ITGA7<\/jats:italic>) was found in highly motile cells. A significant negative correlation was observed between ITGA7<\/jats:italic> transcript levels and average displacement of cells. Forced overexpression of ITGA7<\/jats:styled-content> in MPM<\/jats:styled-content> cells with low endogenous ITGA7<\/jats:italic> expression inhibited cell motility, providing direct evidence for the regulatory role of ITGA7<\/jats:styled-content> in MPM<\/jats:styled-content> cell migration. MPM<\/jats:styled-content> cells showed decreased ITGA7<\/jats:styled-content> expressions at both transcription and protein levels when compared to non\u2010malignant mesothelial cells. The majority of MPM<\/jats:styled-content> cell cultures displayed hypermethylation of the ITGA7<\/jats:styled-content><\/jats:italic> promoter when compared to mesothelial cultures. A statistically significant negative correlation between ITGA7<\/jats:styled-content><\/jats:italic> methylation and ITGA7<\/jats:italic> expression was also observed in MPM<\/jats:styled-content> cells. While normal human pleura samples unambiguously expressed ITGA7<\/jats:styled-content>, a varying level of expression was found in a panel of 200 human MPM<\/jats:styled-content> samples. In multivariate analysis, ITGA7<\/jats:styled-content> expression was found to be an independent prognostic factor. Although there was no correlation between histological subtypes and ITGA7<\/jats:styled-content> expression, importantly, patients with high tumour cell ITGA7<\/jats:styled-content> expression had an increased median overall survival compared to the low\u2010 or no\u2010expression groups (463 versus 278 days). In conclusion, our data suggest that ITGA7<\/jats:styled-content><\/jats:italic> is an epigenetically regulated tumour suppressor gene and a prognostic factor in human MPM<\/jats:styled-content>. Copyright \u00a9 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4567","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T06:22:27Z","timestamp":1432621347000},"page":"203-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Epigenetic down\u2010regulation of integrin \u03b17 increases migratory potential and confers poor prognosis in malignant pleural mesothelioma"],"prefix":"10.1002","volume":"237","author":[{"given":"Viktoria","family":"Laszlo","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center Vienna Medical University of Vienna Austria"},{"name":"Department of Biological Physics E\u00f6tv\u00f6s University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir Alireza","family":"Hoda","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, 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