{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:32:06Z","timestamp":1789176726998,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sir Run Run Shaw Hospital, Zhejiang University (Young Investigator Research Fund), Hangzhou, China"},{"name":"physician rotation programme of Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The derivation of ovarian intestinal\u2010type mucinous tumours is not well established. Some are derived from teratomas but the origin of the majority is not clear. It has been recently proposed that the non\u2010germ cell group may be derived from Brenner tumours, as the association of a mucinous tumour with a Brenner tumour is frequently observed. In order to explore the histogenesis of these neoplasms, we undertook a clonality analysis of the two components of ten combined Brenner and mucinous tumours using a human androgen receptor gene (<jats:styled-content style=\"fixed-case\">HUMARA<\/jats:styled-content>) assay. All eight informative cases of ten showed a concordant X\u2010chromosome inactivation pattern between the two tumour components, indicative of a shared clonal origin (<jats:italic>p<\/jats:italic> = 0.0039). Microsatellite genotyping in five of the combined tumours displayed an identical heterozygous pattern with paired Fallopian tube tissue, indicative of a somatic cell origin. In addition, paired box protein 8, a highly sensitive M\u00fcllerian epithelial marker, was not detected by immunohistochemistry in either tumour component in any of the ten tumours, suggesting that this subset of mucinous tumours does not originate from M\u00fcllerian\u2010derived epithelium. In conclusion, this study demonstrates that in combined mucinous and Brenner tumours, there is a shared clonal relationship between the two different tumour components and suggests that some pure mucinous tumours may develop from a Brenner tumour in which the Brenner tumour component becomes compressed and obliterated by an expanding mucinous neoplasm. Copyright \u00a9 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4572","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T19:39:57Z","timestamp":1434742797000},"page":"146-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Clonality analysis of combined Brenner and mucinous tumours of the ovary reveals their monoclonal origin"],"prefix":"10.1002","volume":"237","author":[{"given":"Yihong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pathology, Sir Run Run Shaw Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Department of Pathology Johns Hopkins Medical Institutions  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u2010chin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions  Baltimore MD 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