{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:08:43Z","timestamp":1768558123993,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T00:00:00Z","timestamp":1440547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR064338-01A1"],"award-info":[{"award-number":["R01AR064338-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>Mesothelioma is a disease of pleural cells lining the lungs which is often caused by exposure to asbestos. The molecular mechanism(s) that regulate the transformation of pleural mesothelioma cells to a migratory and malignant phenotype are unclear. In recent work published in this journal, Laszlo et al<\/jats:italic> performed a set of elegant experiments to identify a key molecular mechanism that may explain the aggressive nature of this disease. Using patient\u2010derived mesothelioma cells with high versus low migratory activity, the authors conducted a genome\u2010wide expression analysis. They identified a significant reduction in ITGA7<\/jats:styled-content><\/jats:italic> expression only in highly migratory malignant pleural mesothelioma cells and showed that loss of ITGA7<\/jats:styled-content><\/jats:italic> expression was associated with methylation of the promoter. Forced expression of integrin \u03b17 reversed the migratory phenotype of these cells. Finally, the authors identified a strong correlation between ITGA7<\/jats:styled-content><\/jats:italic> expression and patient survival. Together, these results identify expression of integrin \u03b17 as a molecular mechanism for the aggressive migratory transformation of mesothelioma and identify a potentially novel diagnostic and therapeutic target. Copyright \u00a9 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4587","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T18:59:31Z","timestamp":1436900371000},"page":"282-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mesothelioma cells breaking bad: loss of integrin \u03b17 promotes cell motility and poor clinical outcomes in patients"],"prefix":"10.1002","volume":"237","author":[{"given":"Dean J","family":"Burkin","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Center for Molecular Medicine University of Nevada School of Medicine 1664\u2009N Virginia Avenue Reno NV 89557 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana M","family":"Fontelonga","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Center for Molecular Medicine University of Nevada School of Medicine 1664\u2009N Virginia Avenue Reno NV 89557 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4567"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051279"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0598-94"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.08.002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.152.6.1207"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.083311"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02952"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk199"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1138"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4587","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.4587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:08:39Z","timestamp":1760958519000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.4587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,26]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/path.4587"],"URL":"https:\/\/doi.org\/10.1002\/path.4587","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,26]]},"assertion":[{"value":"2015-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}