{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:11:42Z","timestamp":1779235902120,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The high\u2010energy requirement of the kidney and the importance of energy metabolism in renal physiology has been appreciated for decades, but only recently has there emerged a strong link between impaired renal energy metabolism and chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>). The mechanisms underlying the association between changes in energy metabolism and progression of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>, however, remain poorly understood. A new study from Qiu and colleagues reported in the <jats:italic>Journal of Pathology<\/jats:italic> has advanced this understanding by showing that, after renal injury, the energy sensor <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content> inhibits epithelial\u2013mesenchymal transition and inflammation, processes important in the pathogenesis of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. Furthermore, this study identifies an interaction between <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CK2\u03b2<\/jats:styled-content> as an important mechanism in the anti\u2010fibrotic effect. <jats:styled-content style=\"fixed-case\">CK2\u03b2<\/jats:styled-content> has previously been shown to interact with <jats:styled-content style=\"fixed-case\">STK11<\/jats:styled-content> (also known as <jats:styled-content style=\"fixed-case\">LKB1<\/jats:styled-content>) to regulate cellular polarity. These findings are consistent with the known roles of the <jats:styled-content style=\"fixed-case\">LKB1\u2013AMPK<\/jats:styled-content> pathway in sustaining cellular energy homeostasis and epithelial cell polarity, and add to growing evidence linking the suppression of energy metabolism to <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. They emphasize the importance of energy metabolism in general and the <jats:styled-content style=\"fixed-case\">LKB1\u2013AMPK<\/jats:styled-content> axis in particular as key investigational and therapeutic targets in the battle against <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. Copyright \u00a9 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4600","type":"journal-article","created":{"date-parts":[[2015,8,22]],"date-time":"2015-08-22T06:26:21Z","timestamp":1440224781000},"page":"407-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Balancing the energy equation for healthy kidneys"],"prefix":"10.1002","volume":"237","author":[{"given":"Peter F","family":"Mount","sequence":"first","affiliation":[{"name":"Department of Nephrology Austin Health  Heidelberg Melbourne Australia"},{"name":"Department of Medicine University of Melbourne  Parkville Melbourne Australia"},{"name":"Institute for Breathing and Sleep Austin Health  Heidelberg Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Nephrology Austin Health  Heidelberg Melbourne Australia"},{"name":"Department of Medicine University of Melbourne  Parkville Melbourne Australia"},{"name":"Institute for Breathing and Sleep Austin Health  Heidelberg Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,10]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1992-9"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3762"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4579"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0942-y"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2008"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.11.004"},{"key":"e_1_2_3_8_1","article-title":"Deletion of Lkb1 in renal tubular epithelial cells leads to CKD by altering metabolism","author":"Han SH","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.235"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00148.2012"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106554"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.44"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3432"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00965.2013"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1250256"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2014.12"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4600","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.4600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:39:16Z","timestamp":1760956756000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.4600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,10]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1002\/path.4600"],"URL":"https:\/\/doi.org\/10.1002\/path.4600","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,10]]},"assertion":[{"value":"2015-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}