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These conditions are characterized by abnormal nutrient homeostasis. One such perturbation is altered metabolism of the sulphur\u2010containing amino acid cysteine. Obesity is associated with elevated plasma cysteine, whereas diabetes is associated with reduced cysteine levels. One mechanism by which cysteine may act is through its enzymatic breakdown to produce hydrogen sulphide (<jats:styled-content style=\"fixed-case\">H<jats:sub>2<\/jats:sub>S<\/jats:styled-content>), a gasotransmitter that regulates glucose and lipid homeostasis. Here we review evidence from both pharmacological studies and transgenic models suggesting that cysteine and hydrogen sulphide play a role in the metabolic dysregulation underpinning obesity and diabetes. We then outline the growing evidence that regulation of hydrogen sulphide levels through its catabolism can impact metabolic health. By integrating hydrogen sulphide production and breakdown pathways, we re\u2010assess current hypothetical models of cysteine and hydrogen sulphide metabolism, offering new insight into their roles in the pathogenesis of obesity and diabetes. \u00a9 2015 The Authors. Pathological Society of Great Britain and Ireland.<\/jats:p>","DOI":"10.1002\/path.4659","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T05:06:25Z","timestamp":1444885585000},"page":"321-332","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Cysteine and hydrogen sulphide in the regulation of metabolism: insights from genetics and pharmacology"],"prefix":"10.1002","volume":"238","author":[{"given":"Roderick N","family":"Carter","sequence":"first","affiliation":[{"name":"Molecular Metabolism Group, University\/BHF Centre for Cardiovascular Sciences, Queens Medical Research Institute University of Edinburgh  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M","family":"Morton","sequence":"additional","affiliation":[{"name":"Molecular Metabolism Group, University\/BHF Centre for Cardiovascular Sciences, Queens Medical Research Institute University of 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