{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:13:38Z","timestamp":1762899218598,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epithelial ovarian cancer (<jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content>), the deadliest of gynaecological cancers, is a disease that remains difficult to detect early and treat efficiently. A significant challenge for researchers in the field is that the aetiology of <jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content> and the molecular pathways important for its development are poorly understood. Moreover, precursor lesions have not been readily identifiable, making the mechanisms of <jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content> progression difficult to delineate. In order to address these issues, several genetically\u2010defined ovarian mouse models have been generated in the past 15 years. However, because of the recent suggestion that most <jats:styled-content style=\"fixed-case\">EOCs<\/jats:styled-content> may not originate from the ovarian surface \u2018epithelium\u2019, but from other tissues of the female genital tract, some models may need to be re\u2010evaluated within this new paradigm. In this review, we examine several genetically\u2010defined <jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content> models and discuss how the new paradigm may explain some of the features of these models. A better understanding of the strengths and limitations of the current <jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content> mouse models will undoubtedly allow us to utilize these tools to better understand the biology of the disease and develop new approaches for <jats:styled-content style=\"fixed-case\">EOC<\/jats:styled-content> prevention, detection, and treatment. Copyright \u00a9 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4663","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T10:08:05Z","timestamp":1445681285000},"page":"180-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Genetically\u2010defined ovarian cancer mouse models"],"prefix":"10.1002","volume":"238","author":[{"given":"Patrice J","family":"Morin","sequence":"first","affiliation":[{"name":"American Association for Cancer Research  Philadelphia PA 19106 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashani T","family":"Weeraratna","sequence":"additional","affiliation":[{"name":"Tumor Microenvironment and Metastasis Program The Wistar Institute  Philadelphia PA 19104 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