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These types of lung cancer are molecularly, phenotypically, and regionally diverse neoplasms, reflecting differences in their cells of origin. <jats:styled-content style=\"fixed-case\">LSCCs<\/jats:styled-content> commonly arise in the airway epithelium of a main or lobar bronchus, which is an important line of defence against the external environment. Furthermore, most <jats:styled-content style=\"fixed-case\">LSCCs<\/jats:styled-content> are characterized histopathologically by the presence of keratinization and\/or intercellular bridges, consistent with the molecular features of these tumours, characterized by high levels of transcripts encoding keratins and proteins relevant to intercellular junctions and cell polarity. In this review, the relationships between the molecular features of <jats:styled-content style=\"fixed-case\">LSCCs<\/jats:styled-content> and the types of cell and epithelia of origin are discussed. Recurrent alterations in genes involved in intercellular adhesion and cell polarity in <jats:styled-content style=\"fixed-case\">LSCCs<\/jats:styled-content> are also reviewed, emphasizing the importance of the disruption of <jats:styled-content style=\"fixed-case\">PAR3<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content> complex. Finally, the possible functional effects of these alterations on epithelial homeostasis, and how they contribute to the development of <jats:styled-content style=\"fixed-case\">LSCC<\/jats:styled-content>, are discussed. Copyright \u00a9 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4686","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T08:17:13Z","timestamp":1452413833000},"page":"606-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cell adhesion and polarity in squamous cell carcinoma of the lung"],"prefix":"10.1002","volume":"238","author":[{"given":"Ester","family":"Bonastre","sequence":"first","affiliation":[{"name":"Genes and Cancer Group, Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL) Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institut Albert Bonniot, INSERM U823 University Joseph Fourier  CHU, Grenoble Hopital Michallon Grenoble 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