{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:13:48Z","timestamp":1791216828668,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T00:00:00Z","timestamp":1459900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973393 & 81071618 & 81272285"],"award-info":[{"award-number":["30973393 & 81071618 & 81272285"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>The tricho\u2013rhino\u2013phalangeal syndrome 1 gene (TRPS1<\/jats:styled-content><\/jats:italic>), which was initially found to be associated with tricho\u2013rhino\u2013phalangeal syndrome, is critical for the development and differentiation of bone, hair follicles and kidney. However, its role in cancer progression is largely unknown. In this study, we demonstrated that down\u2010regulation of TRPS1<\/jats:styled-content> correlated with distant metastasis, tumour recurrence and poor survival rate in cancer patients. TRPS1<\/jats:styled-content> was frequently down\u2010regulated in high\u2010metastatic cancer cell lines from the breast, colon and nasopharynx. Silencing of TRPS1<\/jats:styled-content><\/jats:italic> stimulated epithelial\u2013mesenchymal transition (EMT<\/jats:styled-content>), migration and invasion in vitro<\/jats:italic> and metastasis in vivo<\/jats:italic>, while TRPS1<\/jats:styled-content> over\u2010expression exhibited the opposite effects. Using quantitative proteomics, FOXA1<\/jats:styled-content>, a negative regulator of epithelial\u2013mesenchymal transition (EMT<\/jats:styled-content>), was shown to be down\u2010regulated by TRPS1<\/jats:styled-content><\/jats:italic> knockdown. Ectopic expression of FOXA1<\/jats:styled-content> blocked the enhancement of EMT<\/jats:styled-content>, migration and invasion induced by TRPS1<\/jats:styled-content><\/jats:italic> silencing. Mechanistically, TRPS1<\/jats:styled-content>, acting as a transcription activator, directly induced FOXA1<\/jats:styled-content> transcription by binding to the FOXA1<\/jats:styled-content> promoter. We further showed that down\u2010regulation of TRPS1<\/jats:styled-content> was induced by miR<\/jats:styled-content>\u2010373 binding to the 3\u2032 UTR<\/jats:styled-content> of TRPS1<\/jats:styled-content><\/jats:italic>. Over\u2010expression of TRPS1<\/jats:styled-content><\/jats:italic>, but not TRPS1<\/jats:styled-content> 3\u2032 UTR<\/jats:styled-content><\/jats:italic>, blocked the enhancement of migration and invasion induced by miR<\/jats:styled-content>\u2010373. Taken together, we consider that down\u2010regulation of TRPS1<\/jats:styled-content> by miR<\/jats:styled-content>\u2010373, acting as a transcriptional activator, promotes EMT<\/jats:styled-content> and metastasis by repressing FOXA1<\/jats:styled-content> transcription, expanding upon its previously reported role as a transcription repressor. Copyright \u00a9 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4716","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T15:12:25Z","timestamp":1457795545000},"page":"186-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Down\u2010regulation of TRPS1<\/scp> stimulates epithelial\u2013mesenchymal transition and metastasis through repression of FOXA1<\/scp><\/i>"],"prefix":"10.1002","volume":"239","author":[{"given":"Jin\u2010Zhou","family":"Huang","sequence":"first","affiliation":[{"name":"Institutes of Life and Health Engineering, Jinan University; and Biomedicine Research Centre Third Affiliated Hospital of Guangzhou Medical University People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Institutes of Life and Health Engineering, Jinan University; and Biomedicine Research Centre Third Affiliated Hospital of Guangzhou Medical University People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zeng","sequence":"additional","affiliation":[{"name":"Institutes of Life and Health Engineering, Jinan University; and Biomedicine Research Centre Third Affiliated Hospital of Guangzhou Medical University People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song\u2010Hui","family":"Xu","sequence":"additional","affiliation":[{"name":"Institutes of Life and Health Engineering, Jinan University; and Biomedicine Research Centre Third Affiliated Hospital of Guangzhou Medical University People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei\u2010Yan","family":"Zou","sequence":"additional","affiliation":[{"name":"Institutes of Life and Health Engineering, Jinan University; and Biomedicine Research Centre Third Affiliated Hospital of Guangzhou Medical University People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Chen","sequence":"additional","affiliation":[{"name":"Biomedicine Research Centre and Department of Surgery Third Affiliated Hospital of Guangzhou Medical University People's Republic of China"},{"name":"Key Laboratory for Major Obstetric Diseases of Guangdong Province Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Rong","family":"Yan","sequence":"additional","affiliation":[{"name":"Institutes of Life and Health Engineering, Jinan University; and Biomedicine Research Centre Third Affiliated Hospital of Guangzhou Medical University People's Republic of China"},{"name":"Biomedicine Research Centre and Department of Surgery Third Affiliated Hospital of Guangzhou Medical University People's Republic of China"},{"name":"Key Laboratory for Major Obstetric Diseases of Guangdong Province Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21203"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04872"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.09.022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.01.028"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4416"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-2979"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.169"},{"key":"e_1_2_8_11_1","first-page":"249","article-title":"Autosomal\u2010dominant transmission of the tricho\u2013rhino\u2013phalangeal syndrome. Report of four unrelated families, review of 60 cases","volume":"28","author":"Giedion A","year":"1973","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/71717"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.10.154"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.052316"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn125"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.10.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008091020"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.03.014"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009121201"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-9-119"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.7.1715"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2291"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-011-0067-5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-010-0008-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3557"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4702"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4515"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000539"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.68"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021967"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42328"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201300152"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3468"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001538"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.63"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1681"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.01.012"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.048"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2867-0"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03649"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4582"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4716","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4716","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.4716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:25:03Z","timestamp":1760952303000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.4716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,6]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/path.4716"],"URL":"https:\/\/doi.org\/10.1002\/path.4716","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,6]]},"assertion":[{"value":"2015-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}