{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:46:28Z","timestamp":1762004788264,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,13]],"date-time":"2016-05-13T00:00:00Z","timestamp":1463097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Abstract<\/jats:title>Microglandular adenosis (MGA<\/jats:styled-content>) and atypical MGA<\/jats:styled-content> (AMGA<\/jats:styled-content>) are unusual lesions of the breast. They were once regarded as benign proliferative lesions and innocent bystanders. Several lines of evidence suggested that they could be neoplastic, clonal lesions and a non\u2010obligate precursor for triple\u2010negative breast cancers (TNBC<\/jats:styled-content>). Recent work published in The Journal of Pathology<\/jats:italic> by Guerini\u2010Rocco and colleagues provided further evidence regarding the precursor\u2013product relationship between MGA<\/jats:styled-content>\/AMGA<\/jats:styled-content> and TNBC<\/jats:styled-content>. Using a massively parallel sequencing approach, they demonstrated that MGA<\/jats:styled-content>\/AMGA<\/jats:styled-content>, particularly those associated with TNBC<\/jats:styled-content>, could be clonal neoplastic lesions showing clonal non\u2010synonymous mutations, but none in pure MGA<\/jats:styled-content>. Importantly, those alterations were observed in the associated TNBC<\/jats:styled-content>. They were also able to identify recurrent alterations in TP53<\/jats:styled-content><\/jats:italic> in those MGA<\/jats:styled-content>\/AMGA<\/jats:styled-content> cases as well as their associated TNBC<\/jats:styled-content>. The findings, in conjunction with others, underscore the significance for MGA<\/jats:styled-content> in clinical diagnosis. The potential of a benign lesion to progress into an aggressive malignant tumour implies that modification of the current management approach may be necessary. Copyright \u00a9 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4726","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T13:42:16Z","timestamp":1460295736000},"page":"129-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Microglandular adenosis: a prime suspect in triple\u2010negative breast cancer development"],"prefix":"10.1002","volume":"239","author":[{"given":"Julia YS","family":"Tsang","sequence":"first","affiliation":[{"name":"Department of Anatomical and Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong Ngan Shing Street Shatin NT Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary MK","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology Prince of Wales Hospital, The Chinese University of Hong Kong Ngan Shing Street Shatin NT Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03568.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e32835f2249"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20646"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00906.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604112"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.01858.x"},{"key":"e_1_2_5_8_1","first-page":"113","volume-title":"World Health Organisation Classification of Tumors of the Breast","author":"Lakhani SR","year":"2012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198307080-00002"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31815a87e2"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e32834864f4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199302000-00001"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03432.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2012.04207.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31818af361"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4691"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4726","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.4726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:25:15Z","timestamp":1760952315000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.4726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,13]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1002\/path.4726"],"URL":"https:\/\/doi.org\/10.1002\/path.4726","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"type":"print","value":"0022-3417"},{"type":"electronic","value":"1096-9896"}],"subject":[],"published":{"date-parts":[[2016,5,13]]},"assertion":[{"value":"2016-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}