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We previously reported that reactive oxygen species (<jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>) in the ovulatory follicular fluids (<jats:styled-content style=\"fixed-case\">FFs<\/jats:styled-content>) are mutagenic and cytotoxic to fimbrial epithelial cells, which are bathed in the peritoneal fluid mixed with <jats:styled-content style=\"fixed-case\">FFs<\/jats:styled-content>. Here, we observed that ferryl haemoglobin (Hb), which was abundantly present in ovulatory <jats:styled-content style=\"fixed-case\">FFs<\/jats:styled-content> and pelvic peritoneal fluids, could rescue p53\u2010deficient immortalized fimbrial epithelial (<jats:styled-content style=\"fixed-case\">FE25<\/jats:styled-content>) cells and oviduct epithelial cells from <jats:italic>Trp53<\/jats:italic>\u2010null mice from lethal ovulatory <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> stress. Ferryl Hb and <jats:styled-content style=\"fixed-case\">FF<\/jats:styled-content> containing high Hb levels protected <jats:styled-content style=\"fixed-case\">FE25<\/jats:styled-content> cells from apoptosis, mainly by consuming extracellular <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> and reducing <jats:styled-content style=\"fixed-case\">NADPH<\/jats:styled-content> oxidase\u2010mediated cell death. The remaining extracellular <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content> could still induce <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> double\u2010strand breaks in the fimbrial epithelial cells. Our study revealed that ferryl Hb in peritoneal fluid rescued <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\u2010stressed, <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010damaged fimbrial epithelial cells from death, and suggested that peritoneal blood from various sources may contribute to the ovulation\u2010induced transformation of Fallopian tube epithelium. Copyright \u00a9 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4807","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T04:52:44Z","timestamp":1473828764000},"page":"484-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Haemoglobin in pelvic fluid rescues Fallopian tube epithelial cells from reactive oxygen species stress and apoptosis"],"prefix":"10.1002","volume":"240","author":[{"given":"Hsuan\u2010Shun","family":"Huang","sequence":"first","affiliation":[{"name":"Cervical Cancer Prevention Centre, Department of Research Buddhist Tzu Chi General Hospital  Hualien Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che\u2010Fang","family":"Hsu","sequence":"additional","affiliation":[{"name":"Cervical Cancer Prevention Centre, Department of Research Buddhist Tzu Chi General Hospital  Hualien Taiwan, 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