{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:46:38Z","timestamp":1788295598657,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumour necrosis factor (TNF)\u2010\u03b1 and interleukin (IL)\u201017 are key cytokines driving psoriasis and other inflammatory autoimmune diseases, and thus represent effective targets for anti\u2010psoriatic therapy. In a recent issue of <jats:italic>The Journal of Pathology<\/jats:italic>, Leite Dantas <jats:italic>et al<\/jats:italic> explore a mouse model of TNF\u2010mediated psoriasiform dermatitis and arthritis with doxycyclin\u2010inducible general overexpression of human TNF (ihTNFtg) mice for the contributions of macrophages and T cells in skin inflammation \u2013 with some unexpected and interesting findings. Although T cells are commonly known as major proinflammatory players in psoriasis, in the ihTNFtg mouse model macrophages were the predominant cells causing inflammation, and T cells, represented by Foxp3<jats:sup>+<\/jats:sup> regulatory T cells, mainly formed the opposition to keep inflammation in check. In addition to offering a new perspective on potential alternative initiation mechanisms in psoriatic skin inflammation, this constellation illustrates how cellular networks in inflammatory conditions evolve according to the prevailing cytokine, and may help to explain individual responses to either anti\u2010TNF\u2010\u03b1 or anti\u2010IL\u201017 therapy regimens in psoriasis. Copyright \u00a9 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4820","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T03:43:24Z","timestamp":1476675804000},"page":"3-5","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Skin under <i>Tnf<\/i> influence: how regulatory T cells work against macrophages in psoriasis"],"prefix":"10.1002","volume":"241","author":[{"given":"Martina","family":"Gatzka","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergic Diseases Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015354"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3646"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1931"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4786"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.169"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00751.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27180"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202399"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27179"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151093"},{"key":"e_1_2_4_12_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/ddg.12677","article-title":"T\u2010cell plasticity in inflammatory skin diseases \u2013 the good, the bad, and the chameleons","volume":"13","author":"Gatzka M","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201041205"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.08.003"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.200"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.07.020"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.4820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:21:33Z","timestamp":1760959293000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.4820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,29]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/path.4820"],"URL":"https:\/\/doi.org\/10.1002\/path.4820","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,29]]},"assertion":[{"value":"2016-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}