{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:54:18Z","timestamp":1790744058711,"version":"4.1.0"},"reference-count":204,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["03141376"],"award-info":[{"award-number":["03141376"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["373492"],"award-info":[{"award-number":["373492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The tumour microenvironment plays an instrumental role in cancer development, progression and treatment response\/resistance. Accumulating evidence is underscoring the fundamental importance of epigenetic regulation in tumour immune evasion. Following many pioneering discoveries demonstrating malignant transformation through epigenetic anomalies (\u2018epimutations\u2019), there is also a growing emphasis on elucidating aberrant epigenetic mechanisms that reprogramme the milieu of tumour\u2010associated immune and stromal cells towards an immunosuppressive state. Pharmacological inhibition of\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    methylation and histone modifications can augment the efficiency of immune checkpoint blockage, and unleash anti\u2010tumour T\u2010cell responses. However, these non\u2010specific agents also represent a \u2018double\u2010edged sword\u2019, as they can also reactivate gene transcription of checkpoint molecules, interrupting immune surveillance programmes. By understanding the impact of epigenetic control on the tumour microenvironment, rational combinatorial epigenetic and checkpoint blockage therapies have the potential to harness the immune system for the treatment of cancer. Copyright \u00a9 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.4832","type":"journal-article","created":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T02:12:40Z","timestamp":1477102360000},"page":"10-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Understanding the epigenetic regulation of tumours and their microenvironments: opportunities and problems for epigenetic therapy"],"prefix":"10.1002","volume":"241","author":[{"given":"Man","family":"Liu","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences and State Key Laboratory of Digestive Disease The Chinese University of Hong Kong  Hong Kong SAR PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and State Key Laboratory of Digestive Disease The Chinese University of Hong Kong  Hong Kong SAR PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"AIDS Institute and Department of Microbiology, Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong SAR PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred Sze\u2010Lok","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and State Key Laboratory of Digestive Disease The Chinese University of Hong Kong  Hong Kong SAR PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2703"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.07.017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-013-1434-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1020-6"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.4358"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12626"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa6204"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1609"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1782"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.12.015"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14192"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3486"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205699"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-235176"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvf053"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1473"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2903"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(02)00287-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11606"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02871"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78090"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201100209"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.247445"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2708"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0302-8"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.274"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1102-991"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1860"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06777.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-9002-6"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3581"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.01.011"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-1882"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1252510"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80006"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178331"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12150"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2547"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.020"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.07.006"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2343"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09707"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4472"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4601"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.191"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195300"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06188"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-010-9222-7"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402139"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3258"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.02.010"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.011"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.03.001"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.045"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192461099"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3239"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3518"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03535.x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-013-1511-x"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1965"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.1.240"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-09-046201"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00482"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.28837"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01547-07"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1542"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83671"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21303"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-009-0769-5"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0599"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.428"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2222"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.055"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2526"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2014.08.002"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1673"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0414-210R"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0311119"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1A1014-479R"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002989"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103505"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500209"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301309"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0405"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25921"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.503037"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01495-14"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.11.001"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-217620"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3231"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-130609"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2009.45"},{"key":"e_1_2_9_96_1","article-title":"MicroRNA\u201017, 20a regulates the proangiogenic function of tumor\u2010associated macrophages via targeting hypoxia\u2010inducible factor 2alpha","volume":"8","author":"Xu Z","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2011.12.005"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.258"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402725"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.03.002"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.09.010"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.01.007"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.4"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.121"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxt065"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12003"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2508"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1319"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035128"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3386"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.351"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.9.21.13674"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.140"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08020"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1156"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.479576"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-534313"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-7-21"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2011.87"},{"key":"e_1_2_9_120_1","article-title":"MicroRNA\u201022 impairs anti\u2010tumor ability of dendritic cells by targeting p38","volume":"10","author":"Liang X","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0175-2"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.591420"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00227-8"},{"key":"e_1_2_9_124_1","first-page":"849573","article-title":"Epigenetic control of interferon\u2010gamma expression in CD8 T cells","volume":"2015","author":"Araujo\u2010Souza PS","year":"2015","journal-title":"J Immunol Res"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4547"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112520108"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00798-16"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9941"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76561"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30923"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.8.4253"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.1.418"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521740112"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319269111"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1062968"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1930"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019505"},{"key":"e_1_2_9_138_1","first-page":"29","article-title":"Augmenting antitumor immune responses with epigenetic modifying agents","volume":"6","author":"Heninger E","year":"2015","journal-title":"Front Immunol"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009142"},{"key":"e_1_2_9_140_1","first-page":"3578","article-title":"Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously","volume":"9","author":"Kelly WK","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.14.167"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209678"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20665"},{"key":"e_1_2_9_144_1","first-page":"1766","article-title":"Expression of the MAGE\u20101 tumor antigen is up\u2010regulated by the demethylating agent 5\u2010aza\u20102\u2032\u2010deoxycytidine","volume":"54","author":"Weber J","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23407"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.02.004"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.8.3495"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2012.1508"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24590"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1659"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-3091"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3020"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1452"},{"key":"e_1_2_9_154_1","article-title":"Low dose decitabine treatment induces CD80 expression in cancer cells and stimulates tumor specific cytotoxic T lymphocyte responses","volume":"8","author":"Wang LX","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3021672"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0813435"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-009-0786-4"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2011.08.004"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15520"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.011"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.355"},{"key":"e_1_2_9_162_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69738"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2289"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.12.7017"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12136"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.18804"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.12.3847"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701216"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02689.x"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-5270"},{"key":"e_1_2_9_171_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh326"},{"key":"e_1_2_9_172_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e328364c0ed"},{"key":"e_1_2_9_173_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4252"},{"key":"e_1_2_9_174_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2011.00007"},{"key":"e_1_2_9_175_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.8.5015"},{"key":"e_1_2_9_176_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.229328"},{"key":"e_1_2_9_177_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3339"},{"key":"e_1_2_9_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1652"},{"key":"e_1_2_9_179_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/679804"},{"key":"e_1_2_9_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.04.018"},{"key":"e_1_2_9_181_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.10.037"},{"key":"e_1_2_9_182_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm200773h"},{"key":"e_1_2_9_183_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1111541"},{"key":"e_1_2_9_184_1","first-page":"2562","article-title":"Histone deacetylase inhibition modulates indoleamine 2,3\u2010dioxygenase\u2010dependent DC functions and regulates experimental graft\u2010versus\u2010host disease in mice","volume":"118","author":"Reddy P","year":"2008","journal-title":"J Clin Invest"},{"key":"e_1_2_9_185_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804388"},{"key":"e_1_2_9_186_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0711339"},{"key":"e_1_2_9_187_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2007.02678.x"},{"key":"e_1_2_9_188_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-284711"},{"key":"e_1_2_9_189_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-04-019711"},{"key":"e_1_2_9_190_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-013235"},{"key":"e_1_2_9_191_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-15-0077-T"},{"key":"e_1_2_9_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10673"},{"key":"e_1_2_9_193_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-016-1809-6"},{"key":"e_1_2_9_194_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0b013e318233e5b2"},{"key":"e_1_2_9_195_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3825"},{"key":"e_1_2_9_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.030"},{"key":"e_1_2_9_197_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-2125"},{"key":"e_1_2_9_198_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410626111"},{"key":"e_1_2_9_199_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2584"},{"key":"e_1_2_9_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.131"},{"key":"e_1_2_9_201_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac9935"},{"key":"e_1_2_9_202_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282780"},{"key":"e_1_2_9_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09754"},{"key":"e_1_2_9_204_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-535443"},{"key":"e_1_2_9_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18294"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.4832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:21:47Z","timestamp":1760959307000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.4832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,29]]},"references-count":204,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/path.4832"],"URL":"https:\/\/doi.org\/10.1002\/path.4832","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,29]]},"assertion":[{"value":"2016-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}