{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T06:23:18Z","timestamp":1788675798156,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,15]],"date-time":"2016-12-15T00:00:00Z","timestamp":1481760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["103\u20102311\u2010B\u2010001\u2010024\u2010MY3"],"award-info":[{"award-number":["103\u20102311\u2010B\u2010001\u2010024\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI\u2010EX100\u201010049SI"],"award-info":[{"award-number":["NHRI\u2010EX100\u201010049SI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The transcription factor glial cells missing 1 (GCM1) regulates trophoblast differentiation and function during placentation. Decreased GCM1 expression is associated with pre\u2010eclampsia, suggesting that abnormal expression of GCM1 target genes may contribute to the pathogenesis of pregnancy complications. Here we identified a novel GCM1 target gene, synapse defective 1 (\n                    <jats:italic>SYDE1<\/jats:italic>\n                    ), which encodes a RhoGAP that is highly expressed in human placenta, and demonstrated that SYDE1 promotes cytoskeletal remodelling and cell migration and invasion. Importantly, genetic ablation of murine\n                    <jats:italic>Syde1<\/jats:italic>\n                    results in small fetuses and placentas with aberrant phenotypes in the placental\u2013yolk sac barrier, maternal\u2013trophoblast interface, and placental vascularization. Microarray analysis revealed altered expression of renin\u20101, angiotensin I converting enzyme 2, angiotensin II type 1a receptor, and membrane metalloendopeptidase of the renin\u2013angiotensin system in\n                    <jats:italic>Syde1<\/jats:italic>\n                    \u2010knockout placenta, which may compensate for the vascular defects to maintain normal blood pressure. As pregnancy proceeds, growth restriction of the\n                    <jats:italic>\n                      Syde1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    fetuses and placentas continues, with elevated expression of the Syde1 homologue Syde2 in placenta. Syde2 may compensate for the loss of Syde1 function because SYDE2, but not the GAP\u2010dead SYDE2 mutant, reverses migration and invasion activities of\n                    <jats:italic>SYDE1<\/jats:italic>\n                    \u2010knockdown JAR trophoblast cells. Clinically, we further detected decreased SYDE1 expression in preterm and term IUGR placentas compared with gestational age\u2010matched controls. Our study suggests a novel mechanism for GCM1 and SYDE1 in regulation of trophoblast cell migration and invasion during placental development and that decreased SYDE1 expression is associated with IUGR. Copyright \u00a9 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.\n                  <\/jats:p>","DOI":"10.1002\/path.4835","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T04:29:40Z","timestamp":1480912180000},"page":"324-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth \u2013 SYDE1 regulates placental cell migration and invasion"],"prefix":"10.1002","volume":"241","author":[{"given":"Hsiao\u2010Fan","family":"Lo","sequence":"first","affiliation":[{"name":"Graduate Institute of Biochemical Sciences National Taiwan University  Taipei 106 Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Yen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology Academia Sinica  Nankang Taipei 115 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