{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T16:31:36Z","timestamp":1773765096394,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ovarian high\u2010grade serous carcinoma (<jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>) is the most malignant neoplasm of the gynaecological tract. While the origins of many human malignant neoplasms are clear, the origin of <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> remains poorly understood. This lack of knowledge limits our understanding of its pathogenesis and compromises efforts devoted to developing  better early detection tools and effective preventative interventions. The paradigm of the tubal origin of <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> has been advanced since the initial report of dysplastic lesions (now known as serous tubal intraepithelial carcinomas or <jats:styled-content style=\"fixed-case\">STICs<\/jats:styled-content>) that morphologically resemble <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content> in the Fallopian tube. These were observed in a group of patients with a genetic predisposition to ovarian cancer who were undergoing risk\u2010reducing salpingo\u2010oophorectomy. Since then, a series of clinico\u2010pathological and molecular studies have characterized <jats:styled-content style=\"fixed-case\">STICs<\/jats:styled-content> and their concurrent <jats:styled-content style=\"fixed-case\">HGSCs<\/jats:styled-content>, and the results support the new paradigm of a tubal origin of many \u2018ovarian\u2019 <jats:styled-content style=\"fixed-case\">HGSCs<\/jats:styled-content>. Reactive oxygen species\u2010containing ovulatory follicular fluid has been thought to be the major culprit behind <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage in tubal epithelial cells, leading to either cell death or, if the cells survive, mutagenesis. A recent report from this journal demonstrates that ferryl haemoglobin (Hb) in peritoneal fluid could prevent cell death from <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\u2010damaged fimbrial epithelial cells, facilitating ovulation\u2010induced carcinogenesis of tubal epithelium. This timely study provides new insight into the tumour initiation event in <jats:styled-content style=\"fixed-case\">HGSC<\/jats:styled-content>. Copyright \u00a9 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4875","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T06:12:38Z","timestamp":1483596758000},"page":"3-6","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Tubal origin of ovarian cancer\u00a0\u2013\u00a0the double\u2010edged sword of haemoglobin"],"prefix":"10.1002","volume":"242","author":[{"given":"Shiou\u2010Fu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Gerry","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ie\u2010Ming","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins Medical Institutions  Baltimore Maryland USA"},{"name":"Department of Gynecology and Obstetrics Johns Hopkins Medical Institutions  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.11.011"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1000"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000201826.46978.e5"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213335.40358.47"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822f58bc"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13669-011-0004-1"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31825ec07a"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.3023"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ef7b16"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.2622"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2509"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.60"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.10.013"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4353"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.67"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.101"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4807"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv132"}],"container-title":["The Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpath.4875","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/path.4875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:55:39Z","timestamp":1760954139000},"score":1,"resource":{"primary":{"URL":"https:\/\/pathsocjournals.onlinelibrary.wiley.com\/doi\/10.1002\/path.4875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,23]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1002\/path.4875"],"URL":"https:\/\/doi.org\/10.1002\/path.4875","archive":["Portico"],"relation":{},"ISSN":["0022-3417","1096-9896"],"issn-type":[{"value":"0022-3417","type":"print"},{"value":"1096-9896","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,23]]},"assertion":[{"value":"2016-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}