{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:20Z","timestamp":1786978280736,"version":"build-2736575974"},"reference-count":120,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["2011 ANR\u2010CESA\u2010018\u201001"],"award-info":[{"award-number":["2011 ANR\u2010CESA\u2010018\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>\n \n Bone metastasis affects >70% of patients with advanced breast cancer. However, the molecular mechanisms underlying this process remain unclear. On the basis of analysis of clinical datasets, and\n in vitro<\/jats:italic>\n and\n in vivo<\/jats:italic>\n experiments, we report that the\n \n ZNF217<\/jats:styled-content>\n <\/jats:italic>\n oncogene is a crucial mediator and indicator of bone metastasis. Patients with high\n \n ZNF217<\/jats:styled-content>\n <\/jats:italic>\n mRNA<\/jats:styled-content>\n expression levels in primary breast tumours had a higher risk of developing bone metastases.\n MDA\u2010MB<\/jats:styled-content>\n \u2010231 breast cancer cells stably transfected with\n \n ZNF217<\/jats:styled-content>\n <\/jats:italic>\n (\n MDA\u2010MB<\/jats:styled-content>\n \u2010231\u2010\n ZNF217<\/jats:styled-content>\n ) showed the dysregulated expression of a set of genes with bone\u2010homing and metastasis characteristics, which overlapped with two previously described \u2018osteolytic bone metastasis\u2019 gene signatures, while also highlighting the bone morphogenetic protein (\n BMP<\/jats:styled-content>\n ) pathway. The latter was activated in\n MDA\u2010MB<\/jats:styled-content>\n \u2010231\u2010\n ZNF217<\/jats:styled-content>\n cells, and its silencing by inhibitors (Noggin and\n LDN<\/jats:styled-content>\n \u2010193189) was sufficient to rescue\n ZNF217<\/jats:styled-content>\n \u2010dependent cell migration, invasion or chemotaxis towards the bone environment. Finally, by using non\u2010invasive multimodal\n in vivo<\/jats:italic>\n imaging, we found that\n ZNF217<\/jats:styled-content>\n increases the metastatic growth rate in the bone and accelerates the development of severe osteolytic lesions. Altogether, the findings of this study highlight\n ZNF217<\/jats:styled-content>\n as an indicator of the emergence of breast cancer bone metastasis; future therapies targeting\n ZNF217<\/jats:styled-content>\n and\/or the\n BMP<\/jats:styled-content>\n signalling pathway may be beneficial by preventing the development of bone metastases. Copyright \u00a9 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.\n <\/jats:p>","DOI":"10.1002\/path.4882","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T08:47:08Z","timestamp":1487234828000},"page":"73-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The critical role of the\n ZNF217<\/scp>\n oncogene in promoting breast cancer metastasis to the bone"],"prefix":"10.1002","volume":"242","author":[{"given":"Aur\u00e9lie","family":"Bellanger","sequence":"first","affiliation":[{"name":"Univ. Lyon, Universit\u00e9 Claude Bernard Lyon 1, INSERM U1052, CNRS 5286, Centre L\u00e9on B\u00e9rard, Centre de Recherche en Canc\u00e9rologie de Lyon Lyon France"},{"name":"Univ. 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