{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:45:06Z","timestamp":1791305106739,"version":"4.3.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR1961"],"award-info":[{"award-number":["FOR1961"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KU 1315\/9\u20101"],"award-info":[{"award-number":["KU 1315\/9\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HA1284\/7\u20101"],"award-info":[{"award-number":["HA1284\/7\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Angioimmunoblastic T\u2010cell lymphomas (AITLs<\/jats:styled-content>) frequently carry mutations in the TET2<\/jats:styled-content><\/jats:italic> and IDH2<\/jats:styled-content><\/jats:italic> genes. TET2<\/jats:styled-content><\/jats:italic> mutations represent early genetic lesions as they had already been detected in haematopoietic precursor cells of AITL<\/jats:styled-content> patients. We show by analysis of whole\u2010tissue sections and microdissected PD1<\/jats:styled-content>+<\/jats:sup> cells that the frequency of TET2<\/jats:styled-content><\/jats:italic>\u2010mutated AITL<\/jats:styled-content> is presumably even higher than reported (12\/13 cases in our collection; 92%). In two\u2010thirds of informative AITLs<\/jats:styled-content> (6\/9), a fraction of B cells was also TET2<\/jats:styled-content><\/jats:italic>\u2010mutated. Investigation of four AITLs<\/jats:styled-content> by TET2<\/jats:styled-content><\/jats:italic> and IGHV<\/jats:styled-content><\/jats:italic> gene sequencing of single microdissected B cells showed that between 10% and 60% of polyclonal B cells in AITL<\/jats:styled-content> lymph nodes harboured the identical TET2<\/jats:styled-content><\/jats:italic> mutations of the respective T\u2010cell lymphoma clone. Thus, TET2<\/jats:styled-content><\/jats:italic>\u2010mutated haematopoietic precursor cells in AITL<\/jats:styled-content> patients not only give rise to the T\u2010cell lymphoma but also generate a large population of mutated mature B cells. Future studies will show whether this is a reason why AITL<\/jats:styled-content> patients frequently also develop B\u2010cell lymphomas. Copyright \u00a9 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4898","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T08:18:21Z","timestamp":1490343501000},"page":"129-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["TET2<\/scp><\/i> mutations in B cells of patients affected by angioimmunoblastic T\u2010cell lymphoma"],"prefix":"10.1002","volume":"242","author":[{"given":"Friederike H","family":"Schwartz","sequence":"first","affiliation":[{"name":"Institute of Cell Biology (Cancer Research), University of Duisburg\u2010Essen Medical School Essen Germany"},{"name":"Dr Senckenberg Institute of Pathology, Goethe\u2010University of Frankfurt Medical School Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cai","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology (Cancer Research), University of 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