{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:33:51Z","timestamp":1791657231217,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T00:00:00Z","timestamp":1496966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA008748"],"award-info":[{"award-number":["P30CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>\n \n Sinonasal undifferentiated carcinoma (\n SNUC<\/jats:styled-content>\n ) is a high\u2010grade malignancy with limited treatment options and poor outcome. A morphological spectrum of 47 sinonasal tumours including 17 (36.2%)\n SNUCs<\/jats:styled-content>\n was analysed at genomic level. Thirty carcinomas (cohort 1) were subjected to a hybridization exon\u2010capture next\u2010generation sequencing assay (\n \n MSK\u2010IMPACT\n TM<\/jats:sup>\n <\/jats:styled-content>\n ) to interrogate somatic variants in 279 or 410 cancer\u2010related genes. Seventeen sinonasal tumours (cohort 2) were examined only for the presence of\n \n IDH1<\/jats:styled-content>\n \/2\n <\/jats:italic>\n exon 4 mutations by Sanger sequencing.\n \n IDH2<\/jats:styled-content>\n <\/jats:italic>\n R172<\/jats:styled-content>\n single nucleotide variants were overall detected in 14 (82.4%)\n SNUCs<\/jats:styled-content>\n , in two (20%) poorly\u2010differentiated carcinomas with glandular\/acinar differentiation, and in one of two high\u2010grade neuroendocrine carcinomas, large cell type (\n HGNECs<\/jats:styled-content>\n ). No\n \n IDH2<\/jats:styled-content>\n <\/jats:italic>\n mutation was detected in any of five olfactory neuroblastomas or in any of five\n \n SMARCB1<\/jats:styled-content>\n <\/jats:italic>\n \u2010deficient carcinomas. Among 12\n \n IDH2<\/jats:styled-content>\n <\/jats:italic>\n \u2010mutated cases in cohort 1, five (41.7%) harboured co\u2010existing\n \n TP53<\/jats:styled-content>\n <\/jats:italic>\n mutations, four (33.3%)\n \n CDKN2A<\/jats:styled-content>\n \/\n 2B<\/jats:styled-content>\n <\/jats:italic>\n loss\u2010of\u2010function alterations, four (33.3%)\n \n MYC<\/jats:styled-content>\n <\/jats:italic>\n amplification, and three (25%) had concurrent\n \n SETD2<\/jats:styled-content>\n <\/jats:italic>\n mutations.\n \n AKT1<\/jats:styled-content>\n <\/jats:italic>\n E17K<\/jats:styled-content>\n and\n \n KIT<\/jats:styled-content>\n <\/jats:italic>\n D816V<\/jats:styled-content>\n hotspot variants were each detected in one\n \n IDH2<\/jats:styled-content>\n <\/jats:italic>\n \u2010mutated\n SNUC<\/jats:styled-content>\n .<\/jats:italic>\n The vast majority of\n SNUCs<\/jats:styled-content>\n and variable proportions of other poorly\u2010differentiated sinonasal carcinomas may be amenable to\n IDH2<\/jats:styled-content>\n \u2010targeted therapy. Copyright \u00a9 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.\n <\/jats:p>","DOI":"10.1002\/path.4915","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T11:53:38Z","timestamp":1494503618000},"page":"400-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Frequent\n \n IDH2<\/scp>\n <\/i>\n R172<\/scp>\n mutations in undifferentiated and poorly\u2010differentiated sinonasal carcinomas"],"prefix":"10.1002","volume":"242","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-8946","authenticated-orcid":false,"given":"Snjezana","family":"Dogan","sequence":"first","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J","family":"Chute","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology Sunnybrook Health Sciences Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan N","family":"Ptashkin","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu","family":"Chandramohan","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacklyn","family":"Casanova\u2010Murphy","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khedoudja","family":"Nafa","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin A","family":"Bishop","sequence":"additional","affiliation":[{"name":"Department of Pathology The Johns Hopkins Hospital Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simion I","family":"Chiosea","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B","family":"Stelow","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Ganly","sequence":"additional","affiliation":[{"name":"Department of Surgery Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Katabi","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A","family":"Ghossein","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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AG\u2010221 an oral selective first\u2010in\u2010class potent inhibitor of the IDH2 mutant enzyme induced durable responses in a phase 1 study of IDH2 mutation\u2010positive advanced hematologic malignancies [abstract]. InProceedings of the 20th Congress of the European Hematology Association 11\u201314 June 2015 Vienna Austria. 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