{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:19:07Z","timestamp":1790745547319,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005189","name":"Leukemia Lymphoma Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>Angioimmunoblastic T\u2010cell lymphoma (AITL<\/jats:styled-content>) is one of the most frequent entities of peripheral T\u2010cell lymphoma. An AITL<\/jats:styled-content> has two components: the AITL<\/jats:styled-content> tumour cells, which have a T follicular helper (TFH<\/jats:styled-content>) cell phenotype, and a surrounding and extensive tumour microenvironment that is populated with various reactive cell types, including B cells. Recurrent TET2<\/jats:styled-content><\/jats:italic> mutations have been described in 50\u201380% of AITLs<\/jats:styled-content>, possibly occurring in a haematopoietic progenitor cell. An article published recently in the Journal of Pathology<\/jats:italic> describes the use of microdissection to isolate PD1<\/jats:styled-content>+<\/jats:sup> AITL<\/jats:styled-content> tumour cells and CD20<\/jats:styled-content>+<\/jats:sup> B cells from the AITL<\/jats:styled-content> microenvironment, and to show that TET2<\/jats:styled-content><\/jats:italic> mutations are actually more frequent in these diseases than previously thought. Whereas TET2<\/jats:styled-content><\/jats:italic> mutations were detected in only six of 13 AITLs<\/jats:styled-content>, 12 of 13 samples of microdissected PD1<\/jats:styled-content>+<\/jats:sup> AITL<\/jats:styled-content> tumour cells possessed this mutation. Moreover, TET2<\/jats:styled-content><\/jats:italic> mutations were detected in CD20<\/jats:styled-content>+<\/jats:sup> B cells from the AITL<\/jats:styled-content> microenvironment in six of nine informative cases. These results confirm that TET2<\/jats:styled-content><\/jats:italic> mutation is an early event in the majority of AITL<\/jats:styled-content> cases, and that the driving molecular anomalies are not restricted to the T lineage tumour cells. Copyright \u00a9 2017 Pathological Society of Great Britain and Ireland. 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