{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:32:01Z","timestamp":1789968721636,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["03G0000004A"],"award-info":[{"award-number":["03G0000004A"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01206019"],"award-info":[{"award-number":["R01206019"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monoamine oxidase A (MAOA) is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines and produces H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. It facilitates the progression of gliomas and prostate cancer, but its expression and functional relevance have not been studied in lymphoma. Here, we evaluated MAOA in 427 cases of Hodgkin and non\u2010Hodgkin lymphoma and in a spectrum of reactive lymphoid tissues by immunohistochemistry on formalin\u2010fixed, paraffin\u2010embedded specimens. MAOA was expressed by Hodgkin Reed\u2013Sternberg (HRS) cells in the majority of classical Hodgkin lymphomas (cHLs) (181\/241; 75%), with 34.8% showing strong expression. Weak MAOA was also noted in a minority of primary mediastinal large B\u2010cell lymphomas (8\/47; 17%) and in a mediastinal gray\u2010zone lymphoma. In contrast, no MAOA was found in non\u2010neoplastic lymphoid tissues, nodular lymphocyte\u2010predominant Hodgkin lymphoma (NLPHL; 0\/8) or any other non\u2010Hodgkin lymphomas studied (0\/123). MAOA was more common in Epstein\u2013Barr virus (EBV)\u2010negative compared to EBV\u2010positive cHL (<jats:italic>p<\/jats:italic> &lt; 0.0001) and was especially prevalent in the EBV\u2010negative nodular sclerosing subtype. Similar to primary human lymphoma specimens, most cHL\u2010derived cell lines displayed MAOA activity, whereas non\u2010Hodgkin\u2010lymphoma\u2010derived cell lines did not. The MAOA inhibitor clorgyline reduced the growth of L1236 cells and U\u2010HO1 cells, and shRNA knockdown of MAOA reduced the growth of L1236 cells. Conversely, ectopic overexpression of MAOA increased the growth of MAOA\u2010negative HDLM2 cells. Combined treatment with clorgyline and ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) was more effective in reducing cell growth than either regimen alone. In summary, MAOA is highly expressed in cHL and may reflect the distinct biology of this lymphoma. Further studies on the potential utility of MAOA as a diagnostic marker and therapeutic target are warranted. Copyright \u00a9 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/path.4944","type":"journal-article","created":{"date-parts":[[2017,7,19]],"date-time":"2017-07-19T08:29:42Z","timestamp":1500452982000},"page":"220-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma"],"prefix":"10.1002","volume":"243","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4764-5856","authenticated-orcid":false,"given":"Pei Chuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy University of Southern California  Los Angeles California USA"},{"name":"USC\u2013Taiwan Center for Translational Research, School of Pharmacy University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran N","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"Hematopathology Section, Department of Pathology University of Southern California\u2013Keck School of Medicine  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Mottok","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, Department of Lymphoid Cancer Research BC Cancer Agency  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Y","family":"Loo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Dartmouth\u2010Hitchcock Medical Center  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh Hsi","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Cozen","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Pathology, and Norris Comprehensive Cancer Center, USC Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Steidl","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer, Department of Lymphoid Cancer Research BC Cancer Agency  Vancouver Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Chen","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy University of Southern California  Los Angeles California USA"},{"name":"USC\u2013Taiwan Center for Translational Research, School of Pharmacy University of Southern California  Los Angeles California USA"},{"name":"College of Pharmacy Taipei Medical University  Taipei Taiwan"},{"name":"Department of Cell and Neurobiology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.13.4934"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb09223.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.118"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7792602"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.22.1.197"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.06.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712000715"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308037110"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja512613j"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70982"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.883592"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7283"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603678103"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.07.019"},{"key":"e_1_2_7_16_1","first-page":"146","article-title":"Hodgkin's disease. 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